2022
DOI: 10.1101/2022.05.02.490315
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Syntaxin Habc is required to open Unc18 to template SNARE assembly

Abstract: SNARE and Unc18 proteins form the core of the membrane fusion complex at synapses. The fusion machinery is evolutionarily ancient and mediates constitutive fusion in yeast. We demonstrate that the SNARE and Unc18 machinery in the nematode C. elegans can be replaced by yeast proteins and still carry out synaptic transmission. However, substitutions of individual components from yeast disrupts fusion. To understand the functional interactions within the core machinery we adopted an interspecies complementation a… Show more

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