SyntEyes: A Higher-Order Statistical Eye Model for Healthy Eyes

Abstract

The SyntEyes model produces synthetic biometry that closely resembles clinically measured data, including the normal biological variations in the general population.

SyntEyes KTC: higher order statistical eye model for developing keratoconus

“…This was also seen in the model for normal eyes and was the result of using eigencorneas to reduce dimensionality. 10 The results for manual filtering method showed very similar results as the unfiltered SyntEyes, but the automated filtering generally deviated further from the Table SC1 in Appendix S3).…”

“…These, and several other limitations, were already extensively discussed in the paper on the normal SyntEyes model. 10 One issue specific to the current keratoconus model is that it also produces odd, non-keratoconic topography patterns in about 12-13% of SyntEyes it generates. This issue was dealt with using automatic or manual filtering procedure that produced similar results as either the unfiltered results or the original data.…”

“…11 Next, these parameters were fitted with a linear combination of two multivariate Gaussian functions using Expectation-Maximization, 12 from which it is possible to generate an unlimited number of random biometry sets with the same distributions as the original data. 10,13 Finally, these biometry sets (or Syn-tEyes) were filled in into the Navarro eye model 7 to account for missing parameters, such as e.g. lens asphericity, that are difficult to obtain directly in a clinical setting.…”

“…15,16 For a detailed overview of the parameters, conventions and methods used, we refer to our previous model for healthy eyes. 10…”

Orthogonal basis for the optical transfer function

“…In order to check the accuracy of the approximation supplied by the basis {q m n (r, θ)} m=−n,...,n n=0,1,2,... in the general case given in Eq. (23), we consider one example taken from a data base of OTFs measured in human eyes for a 5 mm pupil diameter [12]. We want to remark that this is a particularly difficult and interesting example, since human eyes present all kinds of aberration modes (Zernike coefficients), so the associated OTF tends to be far from the perfect system q 0 0 (r), and far from the rotational symmetry.…”