Synthese von Pyrrolderivaten

Microwave-assisted synthesis of nitrogen-containing heterocycles

“…Classically, pyrroles were synthesized by various methods viz. Knorr pyrrole synthesis [21], Paal-Knorr synthesis [22], Hantzsch pyrrole synthesis [23], etc.…”

Spectroscopic Studies of Newly Synthesized Steroidal Pyrroles

“…Although construction of pyrrole ring has been done by several methods, for example, the Knorr, 22 Paal-Knorr, 23,24 and Hantzsch syntheses. 25 [3 + 2]-cycloadditions, [26][27][28] multicomponent reactions, [29][30][31] and ring contractions 32 or cyclizations, 33-36 a novel and efficient synthetic method for the synthesis of pyrroles is currently being pursued.…”

Zn(OTf)2 promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives

“…1 The widespread occurrence of pyrrolecontaining compounds in natural products, 2 pharmaceuticals, 3 and organic materials 4 has constantly stimulated organic and medicinal chemists to develop novel strategies for their synthesis and transformations. 5 Although a number of classical methods for constructing pyrrole rings including the Knorr, 6 Hantzsch, 7 and Paal-Knorr reaction 8 have been known for many years, the development of new approaches to afford pyrroles with multifunctional groups and several chiral centers still remains a challenge. Donor-acceptor (D-A) cyclopropanes, which exhibit a high level of reactivity to a wide range of nucleophiles and electrophiles in the presence of a Lewis acid, have been widely applied to the construction of a variety of skeletons, 9 especially five-, six-, seven-membered carbocycles and heterocycles.…”