Synthesen und Reaktionen von Pyridazinderivaten, 3. Mitt.

Heinisch, G.; Luszczak, E.; Pailer, M.

doi:10.1007/bf00910055

Cited by 20 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 1 H NMR spectra of the oximes of pyridazine [124][125][126], pyrimidine [11,[126][127][128][129], pyrazine [124], quinoxaline [130], 1,3,4-triazine [68], and 1,3,4-thiadiazine [120] have been investigated in greatest detail.…”

Section: Structurementioning

confidence: 99%

See 1 more Smart Citation

Oximes of six-membered heterocyclic compounds with two or three hetero-atoms: I. Synthesis and structure (review)

Абеле

Lukevics

2009

Chem Heterocycl Comp

View full text Add to dashboard Cite

Data on methods for the production of and on the structure of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes, and their derivatives are reviewed.The oximes of heterocyclic compounds with two or three heteroatoms are widely used as intermediates in fine organic synthesis. In this review the basic methods for the synthesis of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives are summarized. The basic methods for investigation of the structure of the oximes of six-membered heterocyclic compounds with two or three heteroatoms are discussed in relation to isomerism. The reactions and biological activity of the oximes of heterocyclic compounds with two or three heteroatoms will be examined in the second part of the review.

show abstract

Section: Structurementioning

confidence: 99%

“…IR spectroscopy was also used to study the structure of pyridazine [124], pyrimidine [11], quinazoline [127], quinoxaline [130], and 1,2,4-triazole [67] oximes. In the IR spectrum of 2-pyrimidine aldoxime there is a band for the free OH group at 3600 cm −1 .…”

Section: Structurementioning

confidence: 99%

Oximes of six-membered heterocyclic compounds with two or three hetero-atoms: I. Synthesis and structure (review)

Абеле

Lukevics

2009

Chem Heterocycl Comp

View full text Add to dashboard Cite

show abstract

“…3,6-Dichloropyridazine-4-carboxylic acid chloride 3 was prepared from 3,6-dichloro-4-pyridazinecarboxylic acid with SOCI 2 (Ried and Eichhorn, 1988); 3,6-dichloropyridazine-4-carboxylic acid was available from 3,6-dichloro-4-methylpyridazine via oxidationwith K 2Cr2 0 7 (Heinisch, 1973).…”

Section: Starting Materialsmentioning

confidence: 99%

Pyridazino[3,4-b][1,5]Benzoxazepin-5(6H)-ones: Synthesis and Biological Evaluation

Heinisch

Huber

Leitner

et al. 1996

Antivir Chem Chemother

Self Cite

View full text Add to dashboard Cite

show abstract

“…Starting materials 3,6-Dichloropyridazine-4-carboxylic acid chloride was prepared from 3,6-dichloropyridazine-4-carboxylic acid with SOC1 2 (Ried & Eichhorn, 1988); 3,6-dichloropyridazine-4-carboxylic acid was available from 3,6-dichloro-4-methylpyridazine via oxidation with~Cr207 (Heinisch, 1973). 3,6-Dichloro-N-(2-fluoro-5-methylphenyl)-pyridazine-4-carboxamide (3a) was prepared from 3,6dichloropyridazine-4-carboxylic acid chloride and 2-fluoroaniline (Heinisch et al, 1997a).…”

Section: Introductionmentioning

confidence: 99%

Pyridazino[3,4-b][1,5]Benzodiazepin-5-Ones: Synthesis and Biological Evaluation

Heinisch

Huber

Leitner

et al. 1997

Antivir Chem Chemother

View full text Add to dashboard Cite

Starting from 3,6-dichloropyridazine-4-carboxylic acid chloride, a series of pyridazino[3,4- b][1,5]benzodiazepin-5-ones bearing various substituents in positions 3, 6, 8 and 11 was prepared via N-alkyl-3-alkylamino-6-chloro- N-(2-chloro-5-nitrophenyl)-pyridazine-4-carboxamides. The latter were smoothly accessible by treatment of N-alkyl-3,6-dichloro-N-(2-fluorophenyl)-pyridazine-4-carboxamides with primary aliphatic amines. The new tricyclic compounds, which are structurally related to nevirapine and congeners were screened as human immunodeficiency virus type 1 reverse transcriptase inhibitors; the influence of the substitution pattern on inhibitory potency is discussed.

show abstract

Synthesen und Reaktionen von Pyridazinderivaten, 3. Mitt.

Cited by 20 publications

References 6 publications

Oximes of six-membered heterocyclic compounds with two or three hetero-atoms: I. Synthesis and structure (review)

Oximes of six-membered heterocyclic compounds with two or three hetero-atoms: I. Synthesis and structure (review)

Pyridazino[3,4-b][1,5]Benzoxazepin-5(6H)-ones: Synthesis and Biological Evaluation

Pyridazino[3,4-b][1,5]Benzodiazepin-5-Ones: Synthesis and Biological Evaluation

Contact Info

Product

Resources

About