Syntheses and Biofilm Reducing Effects of l‐Dopa‐Derived Analogues of the Fungal Macrocidins A and Z

Abstract

Four analogues of the fungal metabolites macrocidin A and Z, featuring [13]para‐ or [13]metacyclophanes, were synthesised from fully and orthogonally protected l‐dopa instead of l‐tyrosine. They were tested for antibiotic activities and for effects on the growth and persistence of microbial biofilms. Tentative structure‐activity relationships and distinct differences when compared with the natural lead compounds were identified.