Syntheses and characterization of copper metal complexes prepared from chalcone derivatives

Borge, Vikas Vilas; Patil, Raju M.

doi:10.1016/j.microc.2018.11.001

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…The spectra obtained at room temperature reveal a less amount of hyperfine splitting (Figure ) but in the case of low temperature, good hyperfine splitting is observed. The condition of g || > g ┴ > 2.0023 holds good as the value of g || and g ┴ lies at 2.178 and 2.157 . From the obtained results, it can be concluded that the free electron resides in a dx 2 – y 2 orbital.…”

Section: Resultsmentioning

confidence: 55%

Nanosized divalent transition metal ion‐prompted macrocyclic complexes: Synthesis, characterization, molecular modeling, and biological studies

Sangwan

Singh

2019

J Chinese Chemical Soc

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In the present research work, four new 14-membered tetraazamacrocylic complexes of Cobalt(II), Nickel(II), Copper(II) and Zinc(II) with (1E,14E)- 8,8,17,17-tetramethyl-2,5,11,14-tetraazatricyclo[13.3.1.16,10]icosa-1,5,10,14-tetraene were synthesized using the template methodology that leads to the formation of a complex of type [MLX 2 ] in which L is a macrocyclic ligand derived from ethylenediamine (ED) and 5,5-dimethylcyclohexanedione (DCH) and X = Cl − /CH 3 COO − . Spectroscopic, physical, and analytical characterization of complexes was carried out with the assistance of infra-red, nuclear magnetic resonance, electron spin resonance, Ultraviolet-visible, powder X-Ray diffraction, electron spray ionization -mass spectroscopy (ESI-MS), thermogravimetric analysis, magnetic susceptibilities, and carbon hydrogen nitrogen analysis. The information regarding the monomeric and nonelectrolytic behavior was elucidated from ESI-MS and molar conductance values. Powder X-Ray diffractogram studies point toward the crystalline or amorphous nature of the complexes. All the compounds exhibited the nonelectrolytic nature. Semiempirical calculations were performed using Gaussian 09 software and quantum chemical parameters were determined. Newly designed macrocyclic complexes were examined for their antifungal and antibacterial potency by the Agar well diffusion method. Invitro DNA binding studies were carried out in order to understand the extent and nature of binding shown by the complexes with the DNA. In addition to this, in-silico absorption distribution metabolism excretion toxicity studies were also carried out for the interpretation of drug-like properties in the newly synthesized complexes. K E Y W O R D Santimicrobial, macrocyclic, molecular modeling, template methodology

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Section: Resultsmentioning

confidence: 55%

Nanosized divalent transition metal ion‐prompted macrocyclic complexes: Synthesis, characterization, molecular modeling, and biological studies

Sangwan

Singh

2019

J Chinese Chemical Soc

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“…The versatile design of various metal complexes has been observed due to their diverse oxidation states and coordination properties [2,3]. The metal complexes have been widely used as drugs and diagnostic agents because they have shown easy interactions with different biomolecules and hence contributed to the development of new therapeutic or diagnostic agents [4,5]. In various biological systems, copper shows many spectral and chemical properties due to the presence of different organic ligands in the coordination sphere [6].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Chloride Ions by Copper (II) Complex with Mixed Ligand of Oxindole Derivative and Dithiocarbamates Moiety

et al. 2019

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The present work describes the synthesis of a new copper (II) complex with bidentate ligands based on oxindole (indolin-2-one) derivatives, namely: 1H,1′H,1″H-[2,3′:2′,3″-terbenzo[b]pyrrol]-2″(3″H)-one (L1) and [sodium diethyldithiocarbamate (DTC)] (L2) as a second bidentate ligand. The ligand L1 was prepared by the cyclization reaction of oxindole (2-indolone) with phosphorus oxychloride. A mixed-ligand was synthesized using L1 and L2 ligands with copper (Cu (II)) via a simple reflux process. The synthesized mixed Cu (II) complex [C53H44CuN7O4S2 and [Cu(L1)2(L2)]2H2O] exhibited superior solubility in organic solvents like dichloromethane, chloroform, ethanol, methanol, DMF and DMSO. The optical characterizations revealed that the synthesized Cu (II) complex displayed a broad band (2Eg→2T2g) with the absorption at ~420 nm, suggesting a distorted octahedral geometry due to the strong Jahn-Teller distortion of the Cu2+ ion. The elemental analysis confirmed the existence of Cu, C, S, N, and other elements in the synthesized mixed Cu (II) complex. The physicochemical studies of the organic ligand and Cu(II) complex were investigated by TG analysis, NMR, FTIR, SEM, EDX, electronic spectra and cyclic voltammetry measurements. The detection of chloride ions with the prepared mixed Cu(II) complex was studied by cyclic voltammetry measurements at different scan rates.

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Three Schiff base complexes based on diethylenetriamine: synthesis, structure, DNA binding and cleavage, and in vitro cytotoxicity

Fang

Yan

et al. 2019

Transit Met Chem

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Syntheses and characterization of copper metal complexes prepared from chalcone derivatives

Cited by 9 publications

References 5 publications

Nanosized divalent transition metal ion‐prompted macrocyclic complexes: Synthesis, characterization, molecular modeling, and biological studies

Nanosized divalent transition metal ion‐prompted macrocyclic complexes: Synthesis, characterization, molecular modeling, and biological studies

Electrochemical Detection of Chloride Ions by Copper (II) Complex with Mixed Ligand of Oxindole Derivative and Dithiocarbamates Moiety

Three Schiff base complexes based on diethylenetriamine: synthesis, structure, DNA binding and cleavage, and in vitro cytotoxicity

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