Syntheses and crystal structures of two Schiff-base copper(II) complexes with urease inhibition

Abstract

Two new copper(II) complexes, [CuL1(N 3 )] (1) and [CuL2(NCS, were prepared and structurally characterized by elemental analyses, infrared spectroscopy, and single-crystal X-ray diffraction. Complex 1 is an azide coordinated mononuclear complex, while complex 2 is a terminal thiocyanate coordinated mononuclear complex. The coppers in both complexes are four-coordinate, square-planar. Both complexes show potent urease inhibitory properties.

Synthesis, structure, and urease inhibitory activities of three binuclear copper(II) complexes with protocatechuic acid derivative

“…The results indicate that the inhibitory efficiency of the complex towards urease may be influenced by the transition metal and ligands, and the inhibitory activity probably is due to strong Lewis acid properties of copper ions and the ligands strengthen the inhibitory activity of the complexes. The results are in accord with those reported previously, where some Cu(II) complexes have stronger urease inhibitory activities to urease than their parent ligands and metal ion, with IC 50 ranging from 1 to 50 μM [15,28,[35][36][37][38][39]. Compared with the data reported before, the complexes reported in this study exhibit fairly strong inhibitory activity to urease and may be used as urease inhibitors.…”

Syntheses, Crystal Structures, and Urease Inhibitory Activity of Two Zinc Complexes with 2-[(3-Cyclohexylaminopropylimino)methyl]-6-alkoxyphenol

“…It is notable that both complexes possess stronger urease inhibitory properties than the corresponding Schiff bases and the zinc iodide, but weaker than those of the copper(II) complexes we reported previously. [6,22] FIG. 2.…”

“…A recent research indicated that the Schiff base complexes had potent urease inhibitory activity. [6] Zinc complexes with Schiff bases have attracted much attention in coordination chemistry and bioinorganic chemistry due to their versatile structures and interesting biological properties. [7][8][9][10][11][12] …”

Synthesis, Crystal Structures, and Urease Inhibitory Properties of Two Isostructural Dinuclear Zinc(II) Complexes With Schiff Base 5-Methoxy-2-[(2-methylaminoethylimino)methyl]phenol

“…When compared to those we reported previously, it can be concluded that the urease inhibitory activity of zinc complexes is weaker than those of the copper(II) and cobalt(III) complexes. [18][19][20][21] …”

“…Figures 1 and 2 give perspective views of complexes 1 and 2, respectively. Both complexes crystallize in crystallographic [18] 29.19 ± 0.32 C 13 H 17 Br 3 CuN 2 O [18] 23.63 ± 0.71 C 11 H 13 BrClCuN 5 O [19] 13.0 ± 0.4 C 13 H 16 BrClN 2 O 3 Zn [19] > 100 C 14 H 18 ClCuN 5 O [20] 37.2 ± 0.5 C 14 H 16 ClCuN 3 O 2 S [20] 41.1 ± 0.7 C 53 H 68 Cl 4 Co 2 N 14 O 9 [21] 27.12 ± 0.73 C 14 H 20 Cl 2 N 2 O 3 Zn [21] > 100 HL > 100 Zn(CH 3 COO) 2 > 100 ZnI 2 > 100 Acetohydroxamic acid 45.37 ± 0.31 each other, and are comparable to those reported in the similar Schiff base zinc(II) complexes. [14][15][16] The thiocyanate ligands in 1 are nearly linear and show bent coordination mode with the zinc atoms [N5-C12-S1/Zn1-N5-C12 = 178.8(4) • /173.7(4) • ].…”