Syntheses of Azo-Imine Derivatives from Vanillin as an Acid Base Indicator

Purwono, Bambang; Anwar, Chairil; Hanapi, Ahmad

doi:10.22146/ijc.21318

Cited by 11 publications

(8 citation statements)

References 8 publications

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“…Analytical grade solvents and reagents (Sd fine chemical company India and Sigma Aldrich) were used without further purification for the synthesis of azo imidazole derivatives. The azo aldehyde precursors and amino functionalized imidazole were prepared by following the literature procedure [44] , [45] , [46] , [47] . The IR spectra of the synthesized compounds were measured using Perkin-Elmer Spectrum FT-IR spectrometer (RX-1) in KBr pellets.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (Mpro: 6LU7)

Chhetri¹,

Chettri²,

Rai

et al. 2021

Journal of Molecular Structure

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Highlights Six azo imidazole derivatives have been synthesized and characterized by spectroscopic and analytical tools. Inhibitory potential against main protease (6LU7) have been investigated using computational techniques. Binding energy of the ligands has found in the range −6.7 Kcal/mole to −8.1 Kcal/mole. The order of the ligands towards the protein 6LU7 are L5> L4≈L6>L1>L2>L3.

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Section: Methodsmentioning

confidence: 99%

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (Mpro: 6LU7)

Chhetri¹,

Chettri²,

Rai

et al. 2021

Journal of Molecular Structure

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“…They give sharp color change with the change in pH. Azo dyes are the most popular organic compounds that are used as acid-base indicators for their ability to change color as a function of pH [17,22]. For this reason, this property was investigated in all synthesized Azo dyes (3-14) by using acid-base titrations.…”

Section: Azo Dyes (3-14) As Acid-base Indicatorsmentioning

confidence: 99%

Synthesis and Characterization of New Azo Compounds Linked to 1, 8-Naphthalimide and Studying Their Ability as Acid-Base Indicators

Al-Majidi

Al-Khuzaie

2019

eijs

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New Azo compounds containing an 1,8-naphthalimide moiety were synthesized from 1, 8-naphthalic anhydride by a reaction with p-phenylenediamine or benzidine to produce 1,8-naphthalimide derivatives (1 or 2), which were converted to diazonium salt derivatives by using sodium nitrite and acetic acid at 0-5 áµ’C. The diazonium salt was subjected to a coupling reaction with different substituted phenol in alkaline media at 0-5 áµ’c to produce azo compound derivatives (3-14). The New Azo compound derivatives (3-14) were identified by 1H-NMR, 13C-NMR, and FTIR and by measuring characteristic physical properties and specific reactions. Also, the ability of the prepared azo compounds to work as acid-base indicator was investigated, since azo dyes have different and sharp colors in acidic or basic solutions.

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“…Senyawa ini berpotensi sebagai antioksidan, antimikroba, dan antiinflamasi. Selain itu, senyawa imina dapat juga digunakan sebagai indikator asam-basa (Vibhute, Zangade, Chavan, & Vibhute, 2011;Purwono, Anwar, & Hanapi, 2013). Imina merupakan prekusor dari berbagai jenis obat seperti obat penenang, obat bius, dan obat kontrasepsi (Vibhute et al, 2011).…”

Section: Pendahuluanunclassified

“…Proses sintesis dilakukan dengan penambahan katalis asam (Fessenden & Fessenden, 1982). Purwono, et al (2013) mensintesis senyawa imina dari vanillin dan anilina menggunakan pelarut etanol dengan teknik refluks dengan rendemen sebesar 82,17%.…”

Section: Pendahuluanunclassified

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Green Synthesis Senyawa Imina dari Vanillin and Anilina dengan Katalis Alami Air Jeruk Nipis (Citrus aurantifolia)

Hakimi

Hanapi²,

Fasya³

2018

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Synthesized imine from vanillin and aniline was conducted with solvent-free by adding natural catalyst lime juice (Citrus aurantifolia). This research focused on characterization of imine product using variation of lime juice volume (0.5, 1.0, 1.5, 2.0 and 2.5 mL). Imine product was characterized based on shape, color, melting point and yield. The product was also identified by FITR and GCMS. P1 was e highest yield and purity of imine product were 64.12% and 74.74%, respectively. Physical characterization of imine product was solid form and yellow color with melting point of 150°C.GCMS spectra showed target compound has formed m/z 227 (M *+ ) that referred to 2-metoxy-4-((phenylimino)methyl)phenol. IR spectra confirmed presence of target compound in specific wavelength of imine (C=N) at 1584 cm -1 .Keywords: imine, vanillin, aniline, lime juice, catalyst Sintesis imina dari vanilin dan anilina dapat dilakukan tanpa pelarut dengan bantuan katalis asam alami dari jeruk nipis (Citrus aurantifolia). Penelitian ini bertujuan untuk mengkarakterisasi produk imina dengan variasi volume katalis jeruk nipis. Volume katalis jeruk nipis yang digunakan adalah 0,5; 1,0; 1,5; 2,0; dan 2,5 mL. Produk imina dikarakterisasi berdasarkan bentuk, warna, titik lebur dan rendemen. Produk juga identifikasi menggunakan FTIR dan KG-SM. Sintesis imina menghasilkan P1 sebagai produk terbaik dengan rendemen sebesar 64,12% dan tingkat kemurnian 74,74%. Hasil karakterisasi produk imina berupa padatan yang berwarna kuning dengan titik lebur 150°C. Hasil KG-SM menunjukkan adanya senyawa target sintesis 2-metoksi-4-((fenilimino)metil)fenol pada m/z 227 (M *+ ). Terbentuknya senyawa target diperkuat dengan spektra IR khas senyawa imina (C=N) pada 1584 cm -1 .

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Syntheses of Azo-Imine Derivatives from Vanillin as an Acid Base Indicator

Cited by 11 publications

References 8 publications

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (Mpro: 6LU7)

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (Mpro: 6LU7)

Synthesis and Characterization of New Azo Compounds Linked to 1, 8-Naphthalimide and Studying Their Ability as Acid-Base Indicators

Green Synthesis Senyawa Imina dari Vanillin and Anilina dengan Katalis Alami Air Jeruk Nipis (Citrus aurantifolia)

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