Syntheses of the natural dibenzofuran, ruscodibenzofuran

Abstract

Short syntheses of the natural dibenzofuran, ruscodibenzofuran (1 ) from readily available phenols are described. The key steps involve initial formation of a 2-isopropenylbenzofuran by reaction of an orthohalogenophenol with cuprous isopropenylacetylide followed by cycloaddition of methyl propiolate, to provide a functionalized dibenzofuran.

Nonreductive Deiodination of ortho-Iodo-Hydroxylated Arenes Using Tertiary Amines

“…The enzyme causes deiodination of thyroxin to an inactive form of hormone. Some studies have attempted to study the deiodination by using derivatives of 2,4-diiodophenol to mimic the action of the iodothyronine deiodinases. , In general, deiodination as well as debromination is achieved by various reducing agents such as catalytic hydrogenation, metal hydrides, and acidic conditions such as Pd/C−HCl, Zn or SnCl 2 /CH 3 CO 2 H, Zn/HCl, and CuCN/FeCl 3 . Nevertheless, these methods are time-consuming or complicated or use expensive catalysts.…”