Ralph T. Scannell scite author profile

CMI-977 is a potent 5-lipoxygenase inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI-977, the S,S isomer was found to have the best biological activity and was selected for further development. The enantiomerically pure product was synthesized on a 2-kg scale from (S)-(+)-hydroxymethyl-γ-butyrolactone.

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5-Lipoxygenase inhibitors with histamine H 1 receptor antagonist activity

Lewis¹,

Bayless²,

Eckman³

et al. 2004

Bioorganic & Medicinal Chemistry Letters

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Ralph T. Scannell

DNA cleavage by di- and trihydroxyalkylbenzenes. Characterization of products and the roles of O2, Cu(II), and alkali

DNA strand scission by naturally occurring 5-alkylresorcinols

5-Alkylresorcinols from Hakea trifurcata, that cleave DNA.

Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor

5-Lipoxygenase inhibitors with histamine H 1 receptor antagonist activity

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