Synthesis, absolute configuration and circular dichroism of some diarylmethane derivatives

Whole cell application of Lactobacillus paracasei BD101 to produce enantiomerically pure (S)‐cyclohexyl(phenyl)methanol

“…However, enantioselective reduction of aryl heteroaryl ketones in the presence of biocatalyst is still challenging. [25][26][27][28][29][30] There are a number of studies in the literature that contain cyclohexyl(phenyl) methanone 1 in high enantiomeric selectivity using chemical catalysts [31][32][33][34] ; however, there are very limited studies involving reduction of this compound using biocatalyst, and in these examples, the corresponding chiral secondary alcohols were obtained by low enantiomeric excess (ee) and conversion. 14,15 Biocatalysts have many superiorities compared with classic chemical catalysts.…”

Boron trifluoride etherate-assisted ring opening of ethylene oxide by a chiral organolithium: enantioselective synthesis of (R)-N-Boc-2-(2-hydroxyethyl)pyrrolidine

“…1). Compound 1 is a versatile precursor used in the construction of natural products such as anthramycin, 16 lydicamycin, 17 halosaline, 18 and cuscohygrine, 19 as well as many bioactive molecules such as Clemastine (antihistamine), 20 and SB-269970 (5HT 7 receptor antagonist). 21 The most commonly used methods to synthesize compound (R)-1 involved multi-step sequences from expensive, chiral starting materials such as D D-prolinol or D Dproline, [21][22][23][24] which are not suitable for large-scale synthesis.…”

The inexpensive additive N‐methylmorpholine effectively decreases the equivalents of nucleophiles in the catalytic highly enantioselective arylation of aryl aldehydes

“…Enantiopure diarylmethanols are important structural scaffolds in the synthesis of pharmaceuticals and bioactive compounds. [1][2][3][4][5][6][7][8] Accordingly, the catalytic asymmetric addition of arylmetal reagents and aryl boronic acids to aldehydes has attracted considerable attention over the past decades. [9][10][11][12][13][14][15][16][17] Since Fu and coworkers seminally reported the asymmetric addition with Ph 2 Zn, 18 arylzinc reagents from various aryl sources such as arylboronic acids have been commonly explored for the enantioselective synthesis of diarylmethanols.…”