Synthesis & Analgesic Activity of Mannich & Schiff Bases of 1,5- Benzodiazepines

Abstract

: Benzodiazepines and their polycyclic derivatives are a very important class of bioactive compounds. They are finding numerous new applications and are widely used as anticonvulsant, anti-inflammatory, analgesic, hypnotic, sedative, and antidepressive agents. Hence 1,5-benzodiazepines were synthesized by condensation of o-phenylenediamine and ketones e.g., cyclohexanone in presence of Sulfated Zirconia (catalyst).Mannich bases were synthesized with acetophenone, p-nitroacetophenone, p-chloroacetophenone and formaldehyde. Schiff bases were synthesized using Mannich base of fused ring 1,5-benzodiazepines with p-chloroaniline and p-chlorophenylsemicarbazide in presence of glacial acetic acid. All the synthesized compounds were characterized by 1 H NMR and IR spectral analysis. Synthesized compounds were screened Analgesic ( both central and peripheral activity ) . Compounds NBZD-1. NBZD-3, NBZD-6, NBZD-11, were found to have good peripheral analgesic activity and NBZD-6, NBZD-8, NBZD-9, with good central analgesic activity. © 2011 IGJPS. All rights reserved.