Benzodiazepines have a various behavioral effects in addition to their anxiolytic action. There is every reason to believe that the BZ/GABA receptor complex is involved in these effects, since GABAmimetic manipulations modify the effect of BZ in tests of convulsive activity, motor function, and appetitive behavior. 1,5-Benzodiazepines are biologically important molecules and are extensively used clinically as analgesic, hypnotic, sedative, and antidepressive agents. Hence, 1,5-Benzodiazepines were synthesized by condensation of o-phenylenediamine and ketones, for example, cyclohexanone and acetone in presence of sulfated zirconia (catalyst). Mannich bases were synthesized with acetophenone, p-nitroacetophenone, p-chloroacetophenone, and formaldehyde. Schiff bases were synthesized using Mannich base of 1,5-benzodiazepines with p-chloroaniline and p-chlorophenylsemicarbazide in the presence of glacial acetic acid. All the synthesized compounds were characterized by 1H NMR and IR spectral analyses. All the synthesized derivatives were evaluated at the dose of 30 mg/kg b.w for anticonvulsant activity by isoniazid induced convulsion model, and the compounds NBZD-3 and NBZD-8 were found to be the most active among all compounds. Among all the synthesized derivatives, compounds NBZD-13 and NBZD-17 were found to be the most active among all compounds using thiosemicarbazide induced model. Although NBZD-8, NBZD-10, and NBZD-18 are the compounds which had shown good anticonvulsant activity and have an advantage over that, they were not sedative.

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: Benzodiazepines and their polycyclic derivatives are a very important class of bioactive compounds. They are finding numerous new applications and are widely used as anticonvulsant, anti-inflammatory, analgesic, hypnotic, sedative, and antidepressive agents. Hence 1,5-benzodiazepines were synthesized by condensation of o-phenylenediamine and ketones e.g., cyclohexanone in presence of Sulfated Zirconia (catalyst).Mannich bases were synthesized with acetophenone, p-nitroacetophenone, p-chloroacetophenone and formaldehyde. Schiff bases were synthesized using Mannich base of fused ring 1,5-benzodiazepines with p-chloroaniline and p-chlorophenylsemicarbazide in presence of glacial acetic acid. All the synthesized compounds were characterized by 1 H NMR and IR spectral analysis. Synthesized compounds were screened Analgesic ( both central and peripheral activity ) . Compounds NBZD-1. NBZD-3, NBZD-6, NBZD-11, were found to have good peripheral analgesic activity and NBZD-6, NBZD-8, NBZD-9, with good central analgesic activity. © 2011 IGJPS. All rights reserved.

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