Synthesis and Activity of a New Series of Chalcones as Antibacterial Agents.

Abstract

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Crystal structures of three 1-[4-(4-bromobutoxy)phenyl] chalcone derivatives: (E)-1-[4-(4-bromobutoxy)phenyl]-3-phenylprop-2-en-1-one, (E)-1-[4-(4-bromobutoxy)phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one and (E)-1-[4-(4-bromobutoxy)phenyl]-3-(3,4-dimethoxyphenyl)prop-2-en-1-one

“…Alkoxylated chalcones have been synthesized by the Claisen-Schmidt condensation reaction (Ghosh & Das, 2014) using substituted acetophenones and arylaldehydes in the presence of ethanol and NaOH (Syam et al, 2012) , methanol and NaOH (Kumar et al, 2010), methanol and KOH (Bello et al, 2011), ethanol and KOH (Shenvi et al, 2013) and Mg(HSO4) 2 (Maleraju et al, 2013) under appropriate conditions. Chalcones possess antibacterial (Vibhute et al, 2003), antileishmanial (Nielsen et al, 1998), antimicrobial (Prasad et al, 2006), antituberculosis (Sivakumar et al, 2007), antitumor (Kumar et al, 2003), antihyperglycemic (Satyanarayana et al, 2004) and anticancer activities (Sweety et al, 2010). Methoxy chalcones exhibit anti-mitotic activity (Go et al, 2005) and radical scavenging activity (Yayli et al, 2004).…”

Synthesis of Some Novel (E)-Methyl 2,4-Dimethyl-5-(3-Oxo-3-Phenylprop-1-en-1- Yl)-1h-Pyrrole-3-Carboxylate Derivatives as Antimicrobial Agent

“…Several studies have pointed out the antimicrobial potential of chalcones against a wide range of fungi and bacteria, including resistant ones, clearly indicating that they are attractive target compounds for the discovery and development of new anti-infective agents [4][5][6][7][8][9][10]. These flavonoid family compounds display an impressive area of biological activities, among which antibacterial [11], antifungal [12], antioxidant [13,14], antileishmanial [15], antimalarial [16], angiogenesis inhibitor [17], antiinflammatory [18,19], antiviral [20], antimitotic [21], anticancer [22], anti-invasive [23,24], and antiproliferative [25]. Activities have been cited in the literature.…”

Synthesis, Characterization, and Antimicrobial Evaluation of New N-Phenylcinnamamide Derivatives Linked to Aspirin and Ibuprofen

“…The conjugated ketoethylenic bridge has an important role in the behavior of chalcone moiety due to the delocalization of π electrons between two benzene rings through a bridge which gives it a flexibility in electrons movement during reactions [10], consequently it serves as starting materials for many heterocyclic compounds and therapeutic substances which are used for healing of a lot of illnesses [11]. Chalcones show diversity of pharmacological activities such as anticancer [12], cytotoxic [13], antibacterial [14], antiviral [15,16], and antifungal [17,18].…”