Synthesis and activity of novel tetrazole compounds and their pyrazole-4-carbonitrile precursors against Leishmania spp

Ultrasound mediated green synthesis of pyrano[2,3-c]pyrazoles by using Mn doped ZrO2

“…Among them, pyrazoles annulated heterocyclic derivatives represent an important class of N-containing heterocycles being the main components of many naturally occurring products (Dastan et al, 2012). Pyrazole derivatives have occupied a vital place in drug research because of their various biological and pharmacological activities such as antibacterial (Tanitame et al, 2004), antifungal (Ragavan et al, 2010), antioxidant (Daiane et al, 2014), anticancer , antileishmanial (Faria et al, 2013), hypotensive (Arya et al, 1969), antiallergenic (Parsia et al, 1981) activities etc. Subsequently, several reports for the synthesis of these compounds have been reported including the use of TEA (Litvinov et al, 2009), Per-6-ABCD (Kuppusamy and Kasi, 2010), (Javad et al, 2012), TEABr (Kumar et al, 2007), [Dsim]AlCl 4 (Ahmad et al, 2013), FeNi 3 /SiO 2 /HPGMNP (Mohammad and Seyed, 2013), NaOH/microwave (Kathrotiya and Patel, 2012), Δ/reflux (Zonouz et al, 2012), Δ/CH 3 COOH (Gein et al, 2014), UV (Zou et al, 2011), Microwave (Sharma et al, 2016), Meglumine (Guo et al, 2013), Sproline (Khoobi et al, 2015), ZrO 2 (Saha et al, 2015), Fe 3 O 4 @SiO 2 (Soleimani et al, 2015), 1- (Bodhak et al, 2015) and SnO 2 (Paul et al, 2014).…”

Antimony(III) complexes with 2-amino-4,6-dimethoxypyrimidines: Synthesis, characterization and biological evaluation

“…On the other hands, tetrazoles exhibit appreciable biological activity [21], including glutathione reductase inhibitory activity [22] and antileishmanial activity against Leishmania braziliensis promastigotes [23].…”

Synthesis, single crystal analysis, biological and docking evaluation of tetrazole derivatives

“…Literature survey reveals tetrazoles based heterocycles as potent antileishmanial agents. In this context, Pyrazolyl based tetrazoles are reported to be effective antileishmanial and cytotoxicity agents [16] . Similarly Faiões et al.…”