Synthesis and Anti-cancer Studies of 2, 6-disubstituted Benzothiazole Derivatives

Sadhasivam, Gnanavel; Kulanthai, Kannan; Natarajan, Adhirajan

doi:10.13005/ojc/310224

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Sadhasivam et al. reported the synthesis of 2, 6-disubstituted-BTA by reaction of 2-amino-6-nitrobenzothiazole and acetic anhydride and studied their anticancer activity against three cancer cell lines MCF-7, HeLa and MG63 (human osteosarcoma) The sulphonamide scaffold based BTA 40 (Figure 24) exhibited modest anti-cancer activity with IC 50 of 34.5 µM for MCF-7, 44.15 µM for HeLa and 36.1 µM for the MG63 45 .…”

Section: Bta Derivatives As Anticancer Agentsmentioning

confidence: 99%

Benzothiazole derivatives as anticancer agents

Irfan

Batool

Naqvi

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

185

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Benzothiazole (BTA) belongs to the heterocyclic class of bicyclic compounds. BTA derivatives possesses broad spectrum biological activities such as anticancer, antioxidant, anti-inflammatory, anti-tumour, antiviral, antibacterial, anti-proliferative, anti-diabetic, anti-convulsant, analgesic, anti-tubercular, antimalarial, anti-leishmanial, anti-histaminic and anti-fungal among others. The BTA scaffolds showed a crucial role in the inhibition of the metalloenzyme carbonic anhydrase (CA). In this review an extensive literature survey over the last decade discloses the role of BTA derivatives mainly as anticancer agents. Such compounds are effective against various types of cancer cell lines through a multitude of mechanisms, some of which are poorly studied or understood. The inhibition of tumour associated CAs by BTA derivatives is on the other hand better investigated and such compounds may serve as anticancer leads for the development of agents effective against hypoxic tumours. ARTICLE HISTORY

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Section: Bta Derivatives As Anticancer Agentsmentioning

confidence: 99%

Benzothiazole derivatives as anticancer agents

Irfan

Batool

Naqvi

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

185

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“…N -Arylated heterocyclic compounds are significant organic structural frameworks in various natural products 1 and drugs 2 and they also serve as precursors in aromatic heterocyclic synthesis. 3 2-Aminobenzothiazole derivatives have extensive applications in pharmaceutical chemistry due to their beneficial medicinal properties like anticancer, 4 antidiabetic, 5 antitubercular 6 etc. and hence have generated inquisitiveness among researchers towards their synthesis.…”

Section: Introductionmentioning

confidence: 99%

Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature

Radhika,

Chandravarkar,

Anilkumar

2023

RSC Adv.

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“…The benzimidazole/benzothiazole tethered imidazole derivatives definitely provide leads for further drug development. 30,31 Over the years, researchers have introduced wide variety of catalyst for the synthesis of imidazole derivatives. Reports have revealed that zeolite 32 , p-dodecylbenzenesulfonic acid (DBSA) 33 , DABCO 34 44 , Sodium lauryl sulfate 45 , Cu@ imine/Fe 3 O 4 magnetic nanoparticles 46 , sulfamic acid functionalized hollow magnetic spheres 47 have significantly improved the efficiency but environmental aspects remain overlooked.…”

Section: Introductionmentioning

confidence: 99%

One Pot Synthesis, Characterization of Benzothiazole/ Benzimidazole Tethered Imidazole Derivatives using Clay as Catalyst

Pandey

S.P.Shrivatsva

2021

Orient. J. Chem

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A Green approach for benzothiazole / benzimidazole tethered imidazole derivative synthesis utilizing brick derived clay as a catalyst. Brick clay catalyst used in this synthesis has shown excellent catalytic activity by increasing efficiency, reducing the reaction time and most importantly it is reusable for further reaction runs. These derivatives were synthesized by four component condensation reaction that involvebenzil, aldehyde, 2-aminobenzimidazole / 2-amino-6-nitrobenzothiazole and ammonium acetate. The clay catalyst is characterized by FT-IR while the synthesized derivatives were characterized by FT-IR, 1H NMR and 13C NMR.Brick clay is a cheap, non-hazardous catalyst and can be reused up to many reaction runs with good to excellent yields.

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Synthesis and Anti-cancer Studies of 2, 6-disubstituted Benzothiazole Derivatives

Cited by 8 publications

References 5 publications

Benzothiazole derivatives as anticancer agents

Benzothiazole derivatives as anticancer agents

Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature

One Pot Synthesis, Characterization of Benzothiazole/ Benzimidazole Tethered Imidazole Derivatives using Clay as Catalyst

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