Synthesis and Anti-Hepatitis B Virus Activity of Some 2,3-Dihydroxyprop-1-yl Unnatural Hetaryls

Ashry, El Sayed H. El; Abdel‐Rahman, Adel A.‐H.; Rashed, N.; Rasheed, Hanaa A.

doi:10.1002/(sici)1521-4184(19999)332:9<327::aid-ardp327>3.3.co;2-e

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…Heterocyclic compounds containing acyclic hydroxylated side chains, for example, acyclovir (ACV), are an essential class of antiviral acyclonucleosides (Schaeffer et al, 1978). Therefore, the design of heterocycles incorporates open-chain carbohydrate residues that takes a special interest in the spacious research objects that concentrate on modiication of the acyclic side chain and/or heterocyclic base (Ashry et al, 1999). The purpose of this work was to synthesize and evaluate new series of acyclovir analogues bearing a Schiff base moiety.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antibacterial studies of Schiff bases of acyclovir

Huda

Abdullah²,

Zainab

2020

ijrps

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There is a crucial medical need for the progress of new antibacterial agents with new and more efficient mechanisms. Schiff bases are stated to have a wide range of pharmacological activities, including antimicrobial, antibacterial, antifungal, antioxidant, and anticancer activities, which are largely due to the distinguishing C=N group. Furthermore, heterocyclic compounds containing acyclic hydroxylated side chains, for example, acyclovir (ACV), are an essential class of antiviral acyclonucleosides. Therefore, this work was to synthesize and evaluate a new series of acyclovir analogues bearing a Schiff base moiety. Some of Schiff's bases synthesis in an ethanolic solution of drug, aldehydes, and glacial acetic acid as a catalyst followed in the synthesis of substituted acyclovir drug compounds. In this work, two new series of acyclovir analogues bearing a Schiff base moiety were Synthesised, characterized, and confirmed by various spectral techniques like FTIR, CHN, and 1HNMR spectra, in addition to melting point and retardation factor (Rf.). The biological activity of synthesized Schiff base compounds measured against a panel of various bacteria. The results revealed that these compounds showed antibacterial activity against Gram-positive bacteria such as bacillus and Gram-negative bacteria such as proteus, E-coli, pseudomonas, and klebsiella. It concluded that synthesized Schiff base compounds showed higher antibacterial activity than acyclovir that they derived from it.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antibacterial studies of Schiff bases of acyclovir

Huda

Abdullah²,

Zainab

2020

ijrps

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“…They display a broad spectrum of biological activities such as antibacterial (1,2), antifungal (3), anticancer (4,5), antiinflammatory (6), antiviral (7), and also act as kinase inhibitor (8Á10). Besides these pharmacological activities, quinoxaline derivatives are potential building blocks for the synthesis of organic semiconductor (11,12), electroluminescent material (13,14), DNA cleaving agents (15), dehydroannulenes (16), dyes (17), pesticides (18), corrosion inhibitor (19), chemically controllable switches (20) as well as practical applications such as copper(I) sensor (21), building blocks for dendrimers (22), ligands in metal complexes of supramolecular devices or DNA probes (23Á26).…”

Section: Introductionmentioning

confidence: 99%

N-heterocyclic carbene (thiamine) promoted eco-friendly synthesis of quinoxalines under mild reaction conditions

Singh

Mishra

Srivastava

et al. 2012

Green Chemistry Letters and Reviews

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An efficient and convenient protocol of broad scope for the synthesis of quinoxaline by cyclization-oxidation of phenacyl bromide with equimolar amount of phenylenediamine at room temperature catalyzed by thiamine in the form of N-heterocyclic carbene (NHC). High efficiency, inexpensiveness, and non-toxicity are the interesting features of the catalyst, which make it eco-friendly and highly attractive.

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“…It is well known that the quinoxaline derivatives are used as dyes to detect metals and anions. 1,2 They are also used as agrochemicals, 3 anti-virals, 4 antimicrobials, 5 and for the treatment of tuberculosis, 6 and human cancer cell lines, 7 and herbicides. 8 We have continued our investigations and prepared new quinoxaline derivatives in the hope that they may possess various pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

A convenient synthesis of new pyrazolylquinoxalines from 1,5-benzodiazepine-2-thione

Doumbia¹,

Bouhfid²,

Ahabchane³

et al. 2008

Arkivoc

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Synthesis and Anti-Hepatitis B Virus Activity of Some 2,3-Dihydroxyprop-1-yl Unnatural Hetaryls

Cited by 7 publications

References 4 publications

Synthesis, characterization and antibacterial studies of Schiff bases of acyclovir

Synthesis, characterization and antibacterial studies of Schiff bases of acyclovir

N-heterocyclic carbene (thiamine) promoted eco-friendly synthesis of quinoxalines under mild reaction conditions

A convenient synthesis of new pyrazolylquinoxalines from 1,5-benzodiazepine-2-thione

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