Objective: This study aimed at investigating the relationship between treatment manners, glycemic control, and C-reactive protein (CRP) serum level in patients receiving antidiabetic drugs (ADM) alone or ADM with antihypertensive (AHT) drugs in Basra.Methods: Patients receiving ADM or ADM with AHT drugs, not suffering from complications, were recruited from Al-Mawanee General Hospital in Basra. Socioeconomic characteristics, blood pressure (BP), and treatment plans were recorded. Blood samples were obtained to measure glycated haemoglobin (HbA1c), lipids profile, and high sensitive (hs-CRP).Results: A total of 26 men and 50 women were involved. Lower mean HbA1c was found in patients receiving ADM with AHT drugs compared with those on ADM drugs only (p=0.0013). Lower mean systolic BP (p<0.0001) and diastolic BP (p=0.0078) were found in patients receiving ADM drugs only compared with those receiving ADM with AHT drugs. Lower mean hs-CRP was found in women receiving ADM with AHT drugs compared with those on ADM drugs only. Treatment manners had no effect on mean hs-CRP in men and women receiving ADM with AHT drugs; however, there was a significant direct correlation of hs-CRP with HbA1c (p=0.002) and triglycerides (p=0.009), but inversely with high-density lipoprotein cholesterol (p=0.011) in women receiving ADM drugs only.Conclusion: High levels of hs-CRP are associated with poor glycemic control and dyslipidemia, therefore, consequently increased cardiovascular risk. Due to its value as a risk predictor, hs-CRP should be included in routine monitoring of Type-2 diabetic patients.

There is a crucial medical need for the progress of new antibacterial agents with new and more efficient mechanisms. Schiff bases are stated to have a wide range of pharmacological activities, including antimicrobial, antibacterial, antifungal, antioxidant, and anticancer activities, which are largely due to the distinguishing C=N group. Furthermore, heterocyclic compounds containing acyclic hydroxylated side chains, for example, acyclovir (ACV), are an essential class of antiviral acyclonucleosides. Therefore, this work was to synthesize and evaluate a new series of acyclovir analogues bearing a Schiff base moiety. Some of Schiff's bases synthesis in an ethanolic solution of drug, aldehydes, and glacial acetic acid as a catalyst followed in the synthesis of substituted acyclovir drug compounds. In this work, two new series of acyclovir analogues bearing a Schiff base moiety were Synthesised, characterized, and confirmed by various spectral techniques like FTIR, CHN, and 1HNMR spectra, in addition to melting point and retardation factor (Rf.). The biological activity of synthesized Schiff base compounds measured against a panel of various bacteria. The results revealed that these compounds showed antibacterial activity against Gram-positive bacteria such as bacillus and Gram-negative bacteria such as proteus, E-coli, pseudomonas, and klebsiella. It concluded that synthesized Schiff base compounds showed higher antibacterial activity than acyclovir that they derived from it.