Objective: This study aimed at investigating the relationship between treatment manners, glycemic control, and C-reactive protein (CRP) serum level in patients receiving antidiabetic drugs (ADM) alone or ADM with antihypertensive (AHT) drugs in Basra.Methods: Patients receiving ADM or ADM with AHT drugs, not suffering from complications, were recruited from Al-Mawanee General Hospital in Basra. Socioeconomic characteristics, blood pressure (BP), and treatment plans were recorded. Blood samples were obtained to measure glycated haemoglobin (HbA1c), lipids profile, and high sensitive (hs-CRP).Results: A total of 26 men and 50 women were involved. Lower mean HbA1c was found in patients receiving ADM with AHT drugs compared with those on ADM drugs only (p=0.0013). Lower mean systolic BP (p<0.0001) and diastolic BP (p=0.0078) were found in patients receiving ADM drugs only compared with those receiving ADM with AHT drugs. Lower mean hs-CRP was found in women receiving ADM with AHT drugs compared with those on ADM drugs only. Treatment manners had no effect on mean hs-CRP in men and women receiving ADM with AHT drugs; however, there was a significant direct correlation of hs-CRP with HbA1c (p=0.002) and triglycerides (p=0.009), but inversely with high-density lipoprotein cholesterol (p=0.011) in women receiving ADM drugs only.Conclusion: High levels of hs-CRP are associated with poor glycemic control and dyslipidemia, therefore, consequently increased cardiovascular risk. Due to its value as a risk predictor, hs-CRP should be included in routine monitoring of Type-2 diabetic patients.