Synthesis and anti‐HIV activity of substituted 1,2,4‐triazolo‐thiophene derivatives

Al‐Soud, Yaseen A.

doi:10.1002/hc.20319

Cited by 9 publications

(1 citation statement)

References 30 publications

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“…Several compounds, like Flutrox, Nefazodone, Trazodone, Letrazole, Vorozole, Voriconazole, Posaconazole and etc., are used as drugs in modern medicine. Moreover 1,2,4-triazole and its derivatives possess antifungal, 12 antitubercular, 13 anticancer, 14 anticonvulsant, 15 and anti-HIV 16 properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione

Pachuta‐Stec

Kosikowska

Mazur

et al. 2013

J Chinese Chemical Soc

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The novel N‐(substituted‐thioureido)aminobicyclo dicarboximide and 3,4‐disubstituted 1,2,4‐triazolino‐5‐thione were synthesized and their antimicrobial and antituberculosis activities were examined. Selected dicarboxylic acid anhydrides were used to obtain derivatives of thiosemicarbazide and dicarboximide. Dicarboximides were also cyclized in the presence of an alkaline solution giving 1,2,4‐triazolino‐5‐thione. The chemical structure of all compounds was confirmed by IR, 1H NMR, 13C NMR, the X‐ray crystallography (6, 11) and elemental analysis. Antimicrobial and antituberculosis activities of the derivatives were measured.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione

Pachuta‐Stec

Kosikowska

Mazur

et al. 2013

J Chinese Chemical Soc

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Synthesis and Anticonvulsant Activities of Some Triazolothiadiazole Derivatives

Deng

Dong

Song

et al. 2012

Archiv der Pharmazie

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The present study describes the synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a-4x) and their partially dehydrogenated products 5,6-dihydro-6-substituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (5a-5n). The bioevaluation demonstrated that most compounds in the series of 4a-4x exhibited potent anticonvulsant activity in the maximal electroshock test. Among which, 6-(4-chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (4h) emerged as the most promising candidate on the basis of its favorable ED(50) value of 23.7 mg/kg and PI value of 10.8. In addition, the potency of compound 4h against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline in the chemical-induced seizure tests suggested that compound 4h displayed broad-spectrum activity in several models, and it may exert its anticonvulsant activity through affecting the GABAergic system.

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