2012
DOI: 10.1016/j.bioorg.2011.11.004
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Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids

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Cited by 60 publications
(45 citation statements)
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“…BHMC should be considered a promising drug lead for preclinical and further pharmacological studies. A variety of novel aromatic and heterocyclic aromatic curcuminoids were synthesized, characterized by Khan et al 12 and determined their anti-inflammatory activities by oral administration of female Wistar rats. Among these, four novel curcuminoids notified as RK-97, RK-103, RK-104 and RK-106 in which the bis-methoxy-phenyl group of CUR was replaced with bis-dimethoxybutenolidyl, ascorbate, bis-naphthyl and bis-furanyl derivatives respectively had potent activity in the antiarthritic assay with little gastric or systemic toxicity compared with the vehicle-treated controls.…”
Section: Biological Activities Of Various Curcuminoid Formulationsmentioning
confidence: 99%
See 1 more Smart Citation
“…BHMC should be considered a promising drug lead for preclinical and further pharmacological studies. A variety of novel aromatic and heterocyclic aromatic curcuminoids were synthesized, characterized by Khan et al 12 and determined their anti-inflammatory activities by oral administration of female Wistar rats. Among these, four novel curcuminoids notified as RK-97, RK-103, RK-104 and RK-106 in which the bis-methoxy-phenyl group of CUR was replaced with bis-dimethoxybutenolidyl, ascorbate, bis-naphthyl and bis-furanyl derivatives respectively had potent activity in the antiarthritic assay with little gastric or systemic toxicity compared with the vehicle-treated controls.…”
Section: Biological Activities Of Various Curcuminoid Formulationsmentioning
confidence: 99%
“…It has traditionally been used for medical purposes for many centuries in countries such as India and China for treatment of jaundice and other liver ailments 5, 6. Turmeric is one of the most popular medicinal herbs, with a wide range of pharmacological activities such as antioxidant, 7 anti-protozoal, 8 anti-venom activities, 9 anti-microbial, 10 anti-malarial, 11 anti-inflammatory, 12 anti-proliferative, 13 anti-angiogenic, 14 anti-tumor 15 and anti-aging 16 properties. It has also been used to treat ulcers, parasitic infections, various skin diseases, anti-immune diseases and curing the symptoms of colds and flus 17 .…”
Section: Introductionmentioning
confidence: 99%
“…Khan and co-workers [52] (36) in which curcumin was covalently linked to PEG (35kD). PEGylated curcumin showed enhanced solubility, targeted delivery and greater reduction of cell growth than free curcumin in pancreatic cancer cells.…”
Section: Modifications Of Aryl Sidementioning
confidence: 99%
“…Wichitnithad et al [59] have synthesized a novel series of succinyl-derivatives of three curcuminoids as potential prodrugs (50)(51)(52)(53). Their anti-proliferative activity was evaluated using Caco-2 cells.…”
Section: Modifications Of Aryl Sidementioning
confidence: 99%
“…Curcumin research on synthetic analogs now turned into a stage, where researchers have to focus on identification of pharmacophore which needs to be altered for improving the efficacy as a drug candidate. There has an ongoing debate regarding α, β-unsaturated diketone system exists on curcumin as the reason for magical effect of the drug [17]. The keto-enol isomeric effect on structural pharmacophore may play an important role in binding of this analog with drug target.…”
Section: Introductionmentioning
confidence: 99%