SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 1-(6-NITRO-2H-BENZO[b][1,4]THIAZINE-3(4H)-YLIDENE)HYDRAZINE-1,1-DIOXIDE DERIVATIVES

Abstract

<p><strong>Objective: </strong>The objective of this research was to synthesize and evaluate anti-microbial properties of 1-(6-nitro-2<em>H</em>-benzo[<em>b</em>][1,4]thiazine-3(4<em>H</em>)-ylidene)hydrazine-1,1-dioxide derivatives.</p><p><strong>Methods: </strong>These new compounds were synthesized by reaction of 2<em>H</em>-benzo[b][1,4]thiazin-3(4<em>H</em>)-one with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method.</p><p><strong>Results: </strong>The FTIR, <sup>1</sup>HNMR, <sup>13</sup>CNMR and Mass studies confirms the synthesis of some new 1-(6-nitro-2<em>H</em>-benzo[<em>b</em>][1,4]thiazine-3(4<em>H</em>)-ylidene) hydrazine-1,1-dioxide derivatives. Compound 5f showed potent antimicrobial activity whereas compounds 5c and 5e showed moderate antimicrobial activity.</p><strong>Conclusion: </strong>Result obtained in this research work clearly indicated that the compound 5f having methyl at 2 position and nitro groups at 2′ and 4′ position showed the most potent antimicrobial activity.<p> </p>

A Review: Thiazines Derivatives Treated as Potential Antimicrobial Agents

“…Literature [32][33][34][35][36][37][38][39] revels that thiazines based heterocycles are treated as major group of heterocycles. On the basis of above data, it has been confirmed that a variety of thiazine based heterocycles are believed as probable antimicrobial agents.…”

A Review: Antimicrobial Agents Based on Nitrogen and Sulfur Containing Heterocycles

“…Substituted thiazines ring-based chemical compounds are considered as organic compounds holding four carbon atoms and one N and S atom at various place in the rings containing six members present in various structures. Further, a variety of organic compounds are synthesized by the use of 1, 3 and 1,4 thiazines [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”