Synthesis and antiallergic activity in a series of cinnamic acid

Saraf, A. S.; Simonyan, A. V.

doi:10.1007/bf00777140

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…The N-phenylcinnamamide 1 was synthesized according to the procedure reported in the literature (9). The quinolin-2(1H)-one 2 was synthesized according to the procedure also reported in the literature (10).…”

Section: Scheme and Description Of The Synthesis Of 2-(1piperazinyl)-mentioning

confidence: 99%

Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.

Kubica¹,

Taciak²,

Czajkowska³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

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Cancer is a major public health problem in many countries of the world. It is currently the second leading cause of death in the United States and is expected to surpass heart diseases as the leading cause of death in the next few years (1). Therefore there is a continuous need for the development of new compounds with potential anticancer activity. Carcinogenesis is a complicated process, usually developing over years. The process may be caused by external factors (responsible for up to 80% of cases), and certain genetic factors. In some types of cancer, the overexpression of specific kinases is one of the basic factors of neoplastic transformation. One example is chronic myeloid leukemia (CML), which is a result of genetic mutation leading to formation of pathological BCR-ABL gene encoding a p210 protein, which shows abnormal, increased tyrosine kinase activity. It is assumed that expression of BCR-ABL is an essential factor for neoplastic transformation in CML. The milestone in the treatment of this type of cancer was introduction of selective kinase inhibitors. In the case of CML, tyrosine kinase inhibitor ñ Imatinib (Glivec) due to the high efficacy and good tolerability, it became the ìgold standardî treatment of patients with CML (2).

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Section: Scheme and Description Of The Synthesis Of 2-(1piperazinyl)-mentioning

confidence: 99%

Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.

Kubica¹,

Taciak²,

Czajkowska³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

View full text Add to dashboard Cite

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“…The main utilization of cinnamic acid is in the cosmetic/perfumery industry, especially as methyl, ethyl or benzyl esters (the cinnamic acid and its volatile benzylic ester are responsible for the cinnamon flavor). The cinnamic acid itself, or the p-hydroxy-and p-methoxycinnamic acids, has different pharmaceutical applications, for pulmonary affections, cancer, lupus, infectious diseases (diarrhea, dysentery), possessing antibacterial and antifungal activity (Saraf & Simonyan, 1992;Tawata et al, 1996;Lee et al, 2004). It is also used in food, or for the synthetic ink, resins, elastomers, liquid crystalline polymers and adhesives production.…”

Section: Selective Pertraction Of Cinnamic Acidsmentioning

confidence: 99%

Separation of Biosynthetic Products by Pertraction

Galaction¹,

Caşcaval²

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

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Applications of Pertraction in Biotechnology

Caşcaval

Galaction

Boldureanu

2013

Encyclopedia of Membrane Science and Technology

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Pertraction, also defined as the extraction and transport through liquid membranes, consists in the transfer of a solute between two aqueous phases of different pH values or other chemical properties, phases that are separated by a solvent layer of various sizes. Pertraction efficiency and selectivity can be significantly enhanced by adding one or more carriers, such as organophosphoric compounds, long‐chain amines, or crown ethers, into the liquid membrane, the separation process being called facilitated or synergic pertraction . Compared to the physical or reactive liquid‐liquid extraction, the pertraction method reduces the loss of solvent during the separation cycle, needs small quantity of solvent and carrier due to their continuous regeneration, and offers the possibility of solute transport against its concentration gradient as long as the pH gradient between the two aqueous phases is maintained. In this context, this article overviews representative applications of pertraction for separating individually or selectively the biosynthetic products of carboxylic acids, amino acids, antibiotics, and vitamins. The main influences of the operating parameters on pertraction efficiency, the optimum separation conditions, and the models describing the behavior of pertraction systems are discussed in direct correlation with the practical potential of this separation technique for biotechnology.

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Synthesis and antiallergic activity in a series of cinnamic acid

Cited by 7 publications

References 7 publications

Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.

Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.

Separation of Biosynthetic Products by Pertraction

Applications of Pertraction in Biotechnology

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