1993
DOI: 10.1080/10426509308037396
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Synthesis and Antibacterial Activities of Some New Thieno-[2,3-b]Quinolines

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Cited by 7 publications
(5 citation statements)
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“…Pharmacophore hybridization and hopping of bioactive compound scaffolds are important approaches for the design and development of novel drugs [ 63 ]. Quinolines and their derivatives play important roles in heterocyclic chemistry due to their various biological activities, including antioxidant [ 64 ], anti -plasmodial [ 65 ], anti-inflammatory [ 66 ], anticancer [ 67 ], antibacterial [ 68 ], and antiviral properties [ 69 , 70 ], as well as several other biological activities [ 71 ]. Hydroxy-chloroquine (HCQ) and chloroquine (CQ) are quinoline-based antiplasmodial drugs with repurposing potential for treating COVID-19.…”
Section: Resultsmentioning
confidence: 99%
“…Pharmacophore hybridization and hopping of bioactive compound scaffolds are important approaches for the design and development of novel drugs [ 63 ]. Quinolines and their derivatives play important roles in heterocyclic chemistry due to their various biological activities, including antioxidant [ 64 ], anti -plasmodial [ 65 ], anti-inflammatory [ 66 ], anticancer [ 67 ], antibacterial [ 68 ], and antiviral properties [ 69 , 70 ], as well as several other biological activities [ 71 ]. Hydroxy-chloroquine (HCQ) and chloroquine (CQ) are quinoline-based antiplasmodial drugs with repurposing potential for treating COVID-19.…”
Section: Resultsmentioning
confidence: 99%
“…20−23 Despite thienoquinolines and thienoisoquinolines being poorly represented in nature, they are important compounds in medicinal chemistry. Related compounds exhibit antileukemic 24 and antibacterial activities; 25 also, they were proved as vasodilators. 26 In the light of the prior biological activities of tetrahydroisoquinolines and in resumption of our project for synthesis of new heterocycles containing the thienotetrahydroisoquinolines moiety, 27−34 we have announced here preparation of the new 1-amino-2-substituted and 1-pyrrolyl-2-substituted-5- piperidinyl -6,7,8,9-tetrahydrothieno [2,3-c]isoquinolines and their fused heterocycles which have proved promising antibacterial and antifungal activities parallel to the standard drugs.…”
Section: ■ Introductionmentioning
confidence: 99%
“…NMR (100 MHz, CDCl 3 ):22.11 (C 8 cyclohexeno),22.16 (C 7 cyclohexeno),22.40 (C 4 piperidinyl),24.58 (C 11 , CH 3 acetyl),25.83 (C 3 , C 5 piperidinyl),26.09 (C 6 cyclohexeno),26.85 (C 9 cyclohexeno), 50.94 (C 2 , C 6 piperidinyl), 110.32 (C 3 , C 4 pyrrolyl), 123.11 (C 2 , C 5 pyrrolyl), 123.78 (C 5a ), 123.92 (C 9b ), 135.22 (C 9a ), 136.04 (C 2 ), 144.67 (C 1 ), 157.30 (C 3a ), 163.22 (C 5 ), 192.12 (C10 , CO) ppm. EI−MS (m/z): 379.23 [M + , 68%], 350.20 [M + − CHO, 21%], 323.20 [M + − pyrrolyl-CH 4 , 21%], 296.17 [M + − C 4 H 4 N−OCH 3 , 2%], 84.15 [M + − piperidinyl, 100%].Ethyl 5-(Piperidinyl)-1-(1H-pyrrolyl)-6,7,8,9tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate (5b).…”
mentioning
confidence: 99%
“…In addition, many of the sulfur‐containing fused quinolines such as thienoquinolines have received considerable attention due to their considerable biological and pharmacological activities [22–26]. Moreover, thieno[2,3‐ b ]quinolines exhibit a wide variety of biological activities such as anti‐inflammatory [27], urea transporter inhibitors [28], antitumor [29], antimicrobial [30–32], antioxidant [33], and antiproliferative EGFR tyrosine kinase inhibitors [34].…”
Section: Introductionmentioning
confidence: 99%