Synthesis and Antibacterial Activity of 7-chloro-2–methyl-4H-benzo[d][1,3]–oxazin-4-one and 3–amino-7-chloro-2-methyl quinazolin-4(3H)–one

Analgesic activity of newly synthesized 7-chloro–2–methyl-4H–benzo[d] [1,3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3H)–one

“…The synthesis of 7-chloro-2-methyl-4H-benzo[d] [1,3]-oxazin-4-one (1) and 3-amino-7-chloro-2methyl-quinazolin-4(3H)-one ( 2 ) have been describe in our previous study [20]. This involves the * E-mail address: Osarodion.peter@yahoo.com condensation of 0.76 g (0.005 mol) of 4chloroanthranilate with 1.02 g (10 mL, 0.01 mol) acetic anhydride in 30 mL ethanol medium to yield 7 1, and equimolar amounts of 7-chloro-2-methyl-4Hbenzo[d] [1,3]-oxazin-4-one (1.61 g, 0.01 mol), and hydrazine hydrate (0.51 g, 0.01 mol) were heated under reflux in 30 mL ethanol to give pure 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one (2).…”