Synthesis and antibacterial activity of some new pyrazolone dyes

El‐Kashef, Hussein; Abd‐Alla, Mohamed Hemida; Bayoumi, B. E.; El‐Timawy, A. A. M.

doi:10.1002/jctb.504330604

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…Several biological activities have been established for some pyrazolo derivatives [20,21]. Also, the insecticidal activities have been investigated for some pyrazolo derivatives [22,23]. We reported herein the synthesis of some pyrazolo[1,5-a]pyrimidine from 3-amino-5-phenylamino-1H-pyrazole-4-carboxylic acid (9,10-dioxo-9,10-dihydro-anthracen-2-yl)-amide (3).…”

Section: Chemistrymentioning

confidence: 98%

Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety

Gouda

Berghot

Shoeib

et al. 2010

European Journal of Medicinal Chemistry

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Section: Chemistrymentioning

confidence: 98%

Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety

Gouda

Berghot

Shoeib

et al. 2010

European Journal of Medicinal Chemistry

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“…Several biological activities have been established for some pyrazolo derivatives [24,25]. Also, the insecticidal activities have been investigated for some pyrazolo derivatives [26,27]. We report herein the synthesis of some pyrazolo [1,5-a]pyrimidines from 4,6-dimethyl-1H-pyrazolo [3,4-b]pyridine-3-amine (1).…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and Antioxidant Evaluation of Some New Pyrazolopyridine Derivatives

Gouda

2011

Archiv der Pharmazie

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4,6-Dimethyl-1H-pyrazolo[3,4-b]pyridine-3-amine (1) was used as a key intermediate for the synthesis of imidazolopyrazole derivatives 7-11 upon interaction with 3-(2-bromoacetyl)-2H-chromen-2-one (2), 2-(benzothiazol-2-yl)-4-chloro-3-oxobutanenitrile (3), 2,3-dibromonaphthalene-1,4-dione (4), naphtha[2,3-b]oxirene-2,7-dione (5), 2,5-dichloro-3,6-dihydroxyhexa-2,5-diene-1,4-dione (6), respectively. Acetylation of 11 afforded the bis-acetyl 12. Also, the imidazolopyrimidine 15 was prepared via treatment of 1 with sodium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate (13) in DMF followed by cyclization of the bis-pyrazolopyrimidine 14 with glacial acetic acid. On the other hand, compound 1 was reacted with (E)-1-(4-methoxyphenyl)-5-(piperidin-1-yl)pent-1-en-3-one hydrochloride (16), 2-hydroxy-3-((piperidin-1-yl)-methyl)-naphthalene-1,4-dione (17), 2-styryl-2H-indene-1,3-dione (18), enaminone 22, chloroquinoline-3-carbaldehyde 27a, chloroquinoline-(6-methyl)-3-carbaldehyde 27b and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (28) to afford pyrazolo[3,4-a]pyrimidines 19-21, 23, 29a, 29b and 30, respectively. Also, the pyrazolopyrimidinone 33 was obtained via treatment of 1 with 1-cyanoacetyl-3,5-dimethylpyrazole (31) followed by cyclization of the formed intermediate 32 with glacial acetic acid. Finally, treatment of 1 with o-terephthalaldehyde in glacial acetic acid afforded diazepine 34. The newly synthesized compounds were screened for their antioxidant properties in which some of them exhibited promising activities. Compounds 1, 14, 15, 23, 26, 29a, 30 and 32 have the ability to protect DNA from the damage induced by bleomycin.

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“…Heterocycles containing nitrogen, oxygen and sulphur atoms are time-honored because of their remarkable biological and pharmacological applications [1,2]. Thiazolidinone is a heterocycle that has sulfur, nitrogen and carbonyl group at positions 1, 3 and 4 respectively and represents a ubiquitous scaffold in drug discovery with exceptional pharmacological applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Novel Heterocycles Containing Thiazolidinone and 1,3,4-Oxadiazole Moieties

Kumar¹

2016

Ann Clin Anal Med

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Synthesis and antibacterial activity of some new pyrazolone dyes

Abstract: Some 1 -phenyl-3-methyl-4-(thia-and/or selenadiazolylphenylhydrazo)-A2-pyrazolin-5one derivatives have been prepared and screened in vitro for their antibacterial and antifungal properties.

Cited by 10 publications

References 9 publications

Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety

Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety

Synthesis and Antioxidant Evaluation of Some New Pyrazolopyridine Derivatives

Synthesis and Antimicrobial Activity of Novel Heterocycles Containing Thiazolidinone and 1,3,4-Oxadiazole Moieties

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