Synthesis and Antibacterial Activity of Some New S-Triazole Derivatives

Ghattas, Abd El-Badih A. G.; Moustafa, H. M.; Hassanein, Elsayed; Hussein, Bahgat R. M.

doi:10.1080/10426507.2012.690118

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…A number of heterocyclic compounds containing pyridine ring possess a broad spectrum of biological activities such as: anti‐inflammatory , antibacterial , antifungal , anticancer , antidiabetic , antiviral , antidote , antioxidant , antichagasic , and along with most of the traditional biological activities. In view of these findings and in continuation of our previous work we report herein synthesis of some new pyridine derivatives and tested for anti‐inflammatory and antifungal activity.…”

Section: Introductionsupporting

confidence: 52%

New Heterocyclic Compounds Derived from 4,6‐Diamino‐3‐cyano‐2‐methylthiopyridine and their Biological Activity

Ghattas

Khodairy

Moustafa

et al. 2016

Journal of Heterocyclic Chem

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in Wiley Online Library (wileyonlinelibrary.com).Treatment of 4,6-diamino-3-cyano-2-methylthiopyridine (1) with aqueous KOH or hydrazine hydrate afforded the corresponding nicotinamide 2 and pyrazolo[3,4-b]pyridine 3, respectively. Reaction of compound 1 with bromine, sulfuryl chloride, formaldehyde, or aromatic diazonium salts gave 5bromopyridine 4, 5-chloropyridine 5, dipyridylmethane 6, and azo dyes 7-10, respectively. Compound 1 reacted with diketones to yield the corresponding butenylamino derivative 11 and amides 12-15, respectively. Treatment of butanamide 13 with diazonium salts or a mixture of urea and aromatic aldehyde in the presence of drops of HCl as a catalyst yielded the corresponding arylhydrazones 16-19, pyrimidines 20-24, and 1,8-naphthyridine 25, respectively. The potency of the results as anti-inflammatory and antifungal agents have been evaluated. The compounds have been characterized based on their spectral and elemental analysis.

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Section: Introductionsupporting

confidence: 52%

New Heterocyclic Compounds Derived from 4,6‐Diamino‐3‐cyano‐2‐methylthiopyridine and their Biological Activity

Ghattas

Khodairy

Moustafa

et al. 2016

Journal of Heterocyclic Chem

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“…Mioc et al [23] obtained 1 in good yield by refluxing vii with NaOH (route g) in the presence of ethanol (37). Wand et al in 2016 [31] refluxed viii (route h) with substituted carboxylic acid to acquire 1 (38). Zhao et al 2016 [32] obtained 1 by treating ix (route i) with NaOH in the presence of water and acetic acid (39).…”

Section: Synthetic Strategiesmentioning

confidence: 99%

“…In addition to their interesting biological activities, 1,2,4-triazoles have also played a significant role in synthetic chemistry. They are used in the synthesis of various bioactive heterocyclic compounds such as mannich bases (26), thioureas (5,27,28), thioethers (28,29), schiff bases (29), triazolothiadiazoles (30), triazolothiazines, triazolothiazepines (31) and triazolothiadiazines (30).…”

Section: Introductionmentioning

confidence: 99%

Synthetic and Medicinal Attributes of 1,2,4-Triazole Derivatives

Singla¹

2020

ATMPH

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1,2,4-Triazole is growing as the probable moeity in the mostly rising chemical world of heterocyclic compounds possessing talented pharmacological activities. A number of 1,2,4-triazole comprising drugs are available in market for many ailments in humans and several are in clinical trials. In the last few years, numerous 1,2,4triazole derivatives have been emerged enclosing wide range of biological activities and myriad of new artificial method have been reported to access this scaffold in high yield. This review article covers the recent development of novel 1,2,4-triazoles for numerous biological activities along with the best synthetic strategies.The possible structure-activity relationship of reported 1,2,4-triazole derivatives against the concerned disease was also discussed.

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“…145 Downloaded by [134.117.10.200] at 09: 15 28 November 2014 [3,4-b] [1,3,4]thiadiazines 48 were also prepared by reaction of 4-amino-5-mercapto-s-triazole 1 with bromomalononitrile. 143,147,148 Furthermore, treatment of the aminothiol 1 with diethyl bromomalonate led to the formation of the ethyl thiadiazine-7-carboxylates 49 (Scheme 24).…”

Section: Scheme 21mentioning

confidence: 99%