Synthetic and Medicinal Attributes of 1,2,4-Triazole Derivatives

Abstract

1,2,4-Triazole is growing as the probable moeity in the mostly rising chemical world of heterocyclic compounds possessing talented pharmacological activities. A number of 1,2,4-triazole comprising drugs are available in market for many ailments in humans and several are in clinical trials. In the last few years, numerous 1,2,4triazole derivatives have been emerged enclosing wide range of biological activities and myriad of new artificial method have been reported to access this scaffold in high yield. This review article covers the recent development of novel 1,2,4-triazoles for numerous biological activities along with the best synthetic strategies.The possible structure-activity relationship of reported 1,2,4-triazole derivatives against the concerned disease was also discussed.

Synthesis, Properties and Biological Potential Some Condensed Derivatives 1,2,4-Triazole

“…anticonvulsant [6], antidepressant [7], antiviral [8], anti-inflammatory [9], antinociceptive [10], antidiabetic and antioxidant [11], anticancer [12] agents. In addition, the structure of 1,2,4-triazole is resistant to metabolic transformations and is able to participate in the formation of intermolecular chemical bonds [13]. In addition, 1,2,4-triazole derivatives have low toxicity, good pharmacokinetic and pharmacodynamic parameters [8].…”

Theoretical (B3lyp) and Spectroscopic (Ft-Ir, 1h-Nmr and 13c-Nmr) Investigation of 2- Methoxy-6-[(3-(P-Methylbenzyl)-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)-Azomethin]-Phenyl Benzoate

“…Schiff bases, which contain a triazole ring containing three nitrogen atoms and carry 1,2,4-triazole, have a specific -C=N-imine group in their structure. The 1,2,4-triazole main structure is involved in the structures of many substances with a wide range of biological activities, including insecticides, antimicrobials (Singla, 2020), antituberculous agents (Aly et al, 2020), anticonvulsants (Kopron et al, 2020), anti-inflammatory agents (Abuo-Rahma et al, 2014), analgesics (Patel et al, 2018) antiasthmatic agents (Gao et al, 2019), antidepressants (Shi et al, 2020). Numerous studies have been conducted on Schiff bases that include 1,2,4-triazole to determine if they may be used in biological (Boy et al, 2021;Yüksek et al, 2018;Kotan et al, 2022;, Dharmaraj et al, 2001, chemical (Jin et al, 2018;Kotan et al, 2021) or medicinal applications (Yiğit et al, 2018;Qiao et al, 2011).…”