Synthesis and Antibacterial Investigation of Mn(II) and Co(II) Complexes of Schiffs Base Ligand

Abstract

The metal complexes of transition element derived from Schiffs base ligand widely studied as they are easily prepared, available, low cost materials, have tendency of complexation [1]. The Schiffs base compounds contains the >C=N-linkage which is generally formed by condensation reaction between amine and ketone or aldehyde [2]. From last decades, various applications like antifungal, anticancer, antioxidant, antiviral, antimalarial, anti-inflammotry and antibacterial activities were reported [3]. Schiffs bases generally used as the ligands, have strong tendency to coordinate with the main group metals and transition metals [4]. Metal complexes of Schiffs base stimulated a vigorous interest for the contributions as material [5-9], as they have various applications in the fundamental and the applied sciences [10-12] widely in coordination chemistry [13,14]. Synthesis of new ligand which have different properties and the novel reactivity was perhaps the most important step as the ligands have electron donor and electron acceptor properties, different structural functional groups [15]. Position of ligand in coordination sphere is a major factor of the different studies [16]. Complexes of the multi-donor ligands widely used as they are biological active substances [17]. Thiadiazole derivatives

Salicylic Acid: Synthetic Strategies and Their Biological Activities

“…have synthesised Co(II), Ni(II) and Zn(II) complexes with a Schiff base i. e.2‐hydroxy‐benzoic acid (3,4‐dihydro‐ 2H ‐naphthalen‐1‐ylidene)‐hydrazide (Scheme 41). [51] The reaction involved the refluxing of 2‐hydroxy‐benzoic acid (3,4‐dihydro‐2 H ‐naphthalen‐1‐ylidene)‐hydrazide 151 with metal salts using methanol as a solvent to afford the compounds 152 – 154 . The synthesized compounds were screened for their antibacterial activity.…”