Synthesis and Antibacterial Study of Novel Piperazine Linked Methylene-bis-Coumarins

Abstract

A series of new 6-(2-oxo-3-[(4-arylpiperazino)carbonyl]-2H-6-chromenyl-methyl)-3-[(4- arylpiperazino)carbonyl]-2H-2-chromenone 9(a-j) have been synthesized and tested for their antibacterial activity against human pathogenic strains. The antibacterial evaluation data revealed that the compounds containing 4-methoxyphenyl, 4-fluorophenyl, 4-nitrophenyl and 4-hydroxyphenyl moieties at 4-position of the piperazine ring exhibited potent inhibitory activity towards all the tested bacterial strains. Further, the compounds containing phenyl and 4-methylphenyl moieties showed good activity towards P. aeruginosa and C. violaceum. The 4-nitrophenyl moiety also showed potent activity towards B. subtilis and B. sphaericus.

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“…Given the biological profile of flavones and tetrazole derivatives and our work on synthesizing new heterocyclic compounds [19][20][21][22] , we designed a set of hybrid molecules with different heterocyclic scaffolds, such as flavone and tetrazole intending to increase their antimicrobial activities. In the present study, we report the synthesis of new series of 2phenyl-3-(1-aryl-1H-1, 2, 3, 4-tetraazol-5-yl)-4H-4chromenone 11(a-j) and evaluation of their in-vitro antimicrobial activities.…”