Synthesis and Anticancer Activity of 2-Aryl-3-methylbenzofuro[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-dione and 2-Aryl-3,7,9-trimethylpyrido[3',2':4,5]thieno[3,2-b]pyrazolo[4,3-e]azepine-4,11(2H,10H)-diones

Synthesis and biological evaluation of new 4‐oxo‐thiazolidin‐2‐ylidene derivatives as antimicrobial agents

“…In view of the continuation of our research work to find new effective biologically active azaheterocycles, [ 21‐35 ] the present study focused on the synthesis and antimicrobial activity of 2‐cyano‐ N ‐(furan‐2‐ylmethyl)‐2‐(4‐oxo‐3‐phenylthiazolidin‐2‐ylidene)acetamides. A combinatorial library of these compounds was received from ( E , Z )‐2‐cyano‐ N ‐(furan‐2‐ylmethyl)‐3‐mercapto‐3‐(phenylamino)acrylamide 1 , which was synthesized by the reaction of phenylisothiocyanate 2‐cyano‐ N ‐(furan‐2‐ylmethyl)acetamide.…”

Current trends of chemoinformatics and computer chemistry in drug design: A review

“…The purpose of this work, which is a continuation of our research on the search and analysis of biologically active substances [10][11][12][13][14][15][16][17] is to compile the literature concerning the most important milestones in the development of drug design to outline some of the most used current methods. We are discussing highly effective and powerful techniques for drug discovery and development as well as various methods of Computer aided drug design like molecular docking at virtual screening for lead identification, QSAR, molecular modeling and optimization.…”

Selective Synthesis of Benzofuro[2,3‐c]isoquinolines and 5,6‐Dihydro‐7H‐benzo[c]benzofuro[2,3‐e]azepin‐7‐ones from 4‐Diazoisoquinolin‐3‐ones and Salicylaldehydes

“…Likewise, the only report on the synthesis of benzofuroazepinones in literature comprises condensation/ cyclization protocol between ethyl 4-(2-bromoacetyl)-1-phenyl-1H-pyrazole-3-carboxylate and ortho-hydroxybenzonitrile in the presence of a base. [4] Therefore, devising single step transformations from readily available substrates to access these privileged scaffolds is an area of interest at present.…”

“…On the other hand, benzofuro[2,3‐c]isoquinoline 1 b was reported to be a new blue fluorophore, which exhibited aggregation‐induced emission (AIE) properties [1e] . Similarly, the structural diversity and excellent activity in the preclinical trials for ovarian cancer cells treatment have made benzofuroazepinone 1 c [1f] highly desirable targeted azepinone derivatives for medicinal chemists lately [2]…”

“…Most of these approaches require properly adorned pre‐functionalized substrates that necessitate a multistep synthesis and unwieldly process with poor to moderate overall yields. Likewise, the only report on the synthesis of benzofuroazepinones in literature comprises condensation/ cyclization protocol between ethyl 4‐(2‐bromoacetyl)‐1‐phenyl‐1 H ‐pyrazole‐3‐carboxylate and ortho ‐hydroxybenzonitrile in the presence of a base [4] . Therefore, devising single step transformations from readily available substrates to access these privileged scaffolds is an area of interest at present.…”