Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite

Safaei, Mohsen; Taran, Mojtaba; Rezaei, Razieh; Mansouri, Kamran; Mozaffari, Hamid Reza; Imani, Mohammad Moslem; Sharifi, Roohollah

doi:10.2478/cipms-2019-0007

Cited by 11 publications

(4 citation statements)

References 30 publications

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“…Moreover, a cellulose-magnesium oxide nanocomposite was developed by Safaei and co-researchers [179]. The team optimized the synthetic conditions applying the Taguchi method and subsequently investigated the anticancer efficiency of the obtained samples.…”

Section: Anticancer Activitymentioning

confidence: 99%

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine.

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Section: Anticancer Activitymentioning

confidence: 99%

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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“…The BC intrinsic characteristic is not enough to meet the requirement in dressing materials. The BC acts as a physical barrier against bacterial invention and lacks antibacterial properties to impede bacterial infection itself [72,156]. This decreases the efficiency of BC in treating highly contaminated wounds.…”

Section: Bc-based Wound Dressing As the Drug Delivery Systemmentioning

confidence: 99%

Recent Advances on Bacterial Cellulose-Based Wound Management: Promises and Challenges

Moradpoor

Mohammadi

Safaei

et al. 2022

International Journal of Polymer Science

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Wound healing is a therapeutic challenge due to the complexity of the wound. Various wounds could cause severe physiological trauma and bring social and economic burdens to the patient. The conventional wound healing treatments using bandages and gauze are limited particularly due to their susceptibility to infection. Different types of wound dressing have developed in different physical forms such as sponges, hydrocolloids, films, membranes, and hydrogels. Each of these formulations possesses distinct characteristics making them appropriate for the treatment of a specific wound. In this review, the pathology and microbiology of wounds are introduced. Then, the most recent progress on bacterial cellulose- (BC-) based wound dressing discussed and highlighted their antibacterial and reepithelization properties in vitro and in vivo wound closure. Finally, the challenges and future perspectives on the development of BC-based wound dressing biomaterials are outlined.

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“…Consequently, the nanoparticles exhibit a propitious configuration for biological implementations (15)(16)(17). Magnesium oxide nanoparticles possess potential as a robust and efficacious anticancer agent (18). Nonetheless, a significant constraint of employing metal nanoparticles is their pronounced inclination to aggregate.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells

Sarabikia,

Souri,

Safaei

2023

J Kermanshah Univ Med Sci

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Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.

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Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite

Cited by 11 publications

References 30 publications

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Recent Advances on Bacterial Cellulose-Based Wound Management: Promises and Challenges

Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells

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