Synthesis and anticholinesterase activity of some new fluorogenic analogues of organophosphorus nerve agents

Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase

“…Alibrary of compounds was synthesized including 13 derivatives or 2-alkylamino-3-hydroxypyridines with variation of the amines. To test whether these compounds were capable of reactivation of aged AChE, both 101 (Figure46), a3cyano-4-methylcoumarin analogue of soman (GD), [161,162] and a model phosphate (DFP) were selectedt og enerate methyl-phosphonate-aged and isopropylphosphate-aged formso f AChE.T he OPs were incubated with eeAChE for as ufficient time to ensure the enzyme was completely aged. In the case of 101,adouble aging cycle was employed in which the enzymew as aged and then reactivated with 2-PAM and aged again with the same OP,a nd this procedure ensured al ow baselinef or detecting eventual resurrection of AChE activity.…”

“…A library of compounds was synthesized including 13 derivatives or 2‐alkylamino‐3‐hydroxypyridines with variation of the amines. To test whether these compounds were capable of reactivation of aged AChE, both 101 (Figure ), a 3‐cyano‐4‐methylcoumarin analogue of soman (GD), and a model phosphate (DFP) were selected to generate methylphosphonate‐aged and isopropylphosphate‐aged forms of AChE. The OPs were incubated with eeAChE for a sufficient time to ensure the enzyme was completely aged.…”

Spectroscopic Methods for the Detection of Organophosphate Pesticides – A Preview

“…P=O can obscure absorbance. Agents themselves are not significant absorbers or emitters in the UVVis spectral region 17 unless they are specifically modified with a fluorescent coumarin-type leaving group. 18 With the inclusion of a photoabsorber material, such as a porphyrin, photocatalytic degradation of acephate and monocrotophos in the presence of TiO 2 indicated that the decomposition of acephate begin from the destruction of C-N and P-N bonds.…”

LiI/TBHP Mediated Oxidative Cross‐Coupling of P(O)–H Compounds with Phenols and Various Nucleophiles: Direct Access to the Synthesis of Organophosphates

“…Recent discoveries of numerous natural organophosphates endowed with interesting activities in both agricultural and medicinal fields have encouraged the development of synthetic analogues , . As illustrated in Figure , paraoxon, cyanophos, methyl parathion, temefos, coroxon and DEPFMU are well known pesticides . Moreover, Phosphate esters are tunable reagents and functional groups in organic synthesis .…”