Synthesis and anticonvulsant activity of new phenytoin derivatives

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

“…Epilepsy is considered as one of the most common neurological disorders, afflicting around 50 million people worldwide [158,159]. This condition is characterized by neuronal hyperexcitability and firing [160,161].…”

Latest Update on Pharmacological Activities of 1,3,4-Oxadiazole Derivatives

“…The neurotoxicity was determined applying the rotarod test. Among these compounds 4 showed the highest protection (80%) in the scPTZ test at a dose of 100 mg/kg [3] (Figure 3).…”

“…Oxadiazole is considered to be derived from furan by replacement of two methane (-CH=) group by two pyridine type nitrogen (-N=). There are four possible isomers of oxadiazole (1,2,3,4) depending on the position of nitrogen atom in the ring and are numbered as shown in Figure 1.…”

A new direct synthetic access to 4-amino-2-N-(glycosyl/propyl)-1,2,4-triazole-3-thiones via hydrazinolysis of 3-N-((acylated glycosyl)/allyl)-1,3,4-oxadiazole-2-thiones

“…It is well known that reaction of hydrazine hydrate with 1,3,4-oxadiazolethione IV in ethanol gives 4-amino-1,2,4-triazole-thione I. [1][2][3][4][5][6][7][8][9][10][11][12][13] We wondered what would happen in its reaction with S-alkylated 1,3,4-oxadiazoles V and N-alkylated 1,3,4-oxadiazole-thiones VI. We doubted the report 19 that reaction of V with hydrazine hydrate leads to replacement of S-alkyl with a hydrazino group without breakdown of the oxadiazole moiety.…”

“…They show antimicrobial, [1][2][3][4][5][6][7] antiproliferative, 8 antituberculosis, [9][10][11] anticonvulsant, 12 analgesic, 13 anti-inflammatory, 14 antitumor 15 and antidepressant 16 activities in addition to their inhibitory activity of trans-cinnamate 4-hydroxylase 17 and urease 18 enzymes. On this basis, searching for the synthesis of new 4-amino-1,2,4-triazole-thione derivatives is justified.…”