Synthesis and Anticonvulsant Activity of Some Cyclohexanone Derivatives – Knoevenagel Condensation Products

Kocharov, S. L.; Panosyan, G. A.; Jaghatspanyan, I. A.; Nazaryan, I. M.; Hakobyan, H. G.

doi:10.1007/s11094-020-02305-9

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Chalcone derivatives containing the ketoethylenic group (-CO-CH=CH-) provide a rich source for the synthesis of optically active compounds [ 3 ]. These derivatives have great potential for applications due to their specific electronic structures (i.e., a completely delocalized electron system) [ 4 ], photophysical properties [ 5 , 6 , 7 ], and biological activities, such as being antimicrobial [ 8 ], antioxidant [ 9 ], anticonvulsant [ 10 ], inhibitors of inflammatory markers [ 11 ], and antifungal agent [ 12 ]. In recent years, dibenzylidene cyclohexanone derivatives have been used as corrosion inhibitors [ 13 ], fluorescent sensors for detecting Hg 2+ [ 14 ], and chromium ions in aqueous media [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Solvatochromism, Acidochromism and Photochromism of the 2,6-Bis(4-hydroxybenzylidene) Cyclohexanone Derivative

Homocianu¹,

Serbezeanu²,

Vlad‐Bubulac³

2023

IJMS

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In this paper, we studied the photophysical behavior of 2,6-bis(4-hydroxybenzylidene) cyclohexanone (BZCH) under the influence of various stimuli. The photophysical properties were correlated with different solvent parameters, such as the Kamlet–Abraham–Taft (KAT), Catalán, and Laurence solvent scales, suggesting that the behavior of BZCH is influenced by both nonspecific and specific solvent-solute interactions. The Catalán solvent dipolarity/polarizability parameters were found to have a significant role in the solvatochromic behavior, which is also confirmed by the KAT and Laurence models. The acidochromism and photochromism properties of this sample in dimethylsulfoxide and chloroform solutions were also investigated. The compound showed reversible acidochromism after the addition of dilute NaOH/HCl solutions, accompanied by a change in color and the appearance of a new absorption band (514 nm). The photochemical behavior was also examined by irradiating BZCH solutions with both 254 and 365 nm light.

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