Synthesis and antifungal activity of 1-substitutedphenyl-3-(5-halobenzimidazol-2-yl) acylurea

Abstract

Twelve novel compounds of 1-substitutedphenyl-3-(5-halobenzimidazol-2-yl) acylurea were synthesized by the reaction of 5-halobenzimidazol-2-yl acylisocyanate with substituted anilines in yields of 62.4-76.1%. The structures of the title compounds were characterized by IR, 1 H NMR spectra and elemental analysis. Antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were also evaluated by the mycelium growth rate method in the lab. The results indicated that most of the title compounds exhibited excellent antifungal activities against Sclerotinia sclerotiorum, and their activities were higher than that of thiophanatemethyl.

Anti-Leishmanial and Cytotoxic Activities of a Series of Maleimides: Synthesis, Biological Evaluation and Structure-Activity Relationship

“…The structures of all the compounds were determined by IR, EI–MS, 1 H-NMR. Note that compounds 1 – 12 , 17 , 21 , 22 , 28 – 37 had been previously reported [ 27 , 33 , 39 , 40 , 41 , 42 , 43 ], which were coincident with the previous report by EI MS and 1 H-NMR. Physical and spectroscopic data of the other compounds were shown in the supplementary material .…”

Synthesis and antifungal evaluation of a series of maleimides

“…The compounds I‐1 to I‐12 , I‐21 , II‐6 to II‐9 and III‐1 to III‐12 have been previously reported . The structures of all the compounds were confirmed by IR, ESI‐MS and 1 H NMR.…”

Synthesis and antifungal activity of novel 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety

“…16,17) e tested pathogens, Botrytis cinerea (BC-JfC02) and Sclerotinia scleroiorum (SS-JSZ01) were both collected from Tai'an city, China, and stored in Key Laboratory of Pesticide Toxicology and Application Technique of Shandong Province. Moreover, the S. sclerotiorum is benzimidazole-sensitive strain, while the B. cinerea is benzimidazole moderately-resistant strain.…”