Synthesis and Antifungal Activity of Some New Fluorine-Substituted 4-Thiazolidinone Bearing 1,2,4-Triazinone

Abstract

Fluorine substituted 4-thiazolidinone 5 bearing 1,2,4-triazinone obtained from the condensation of 3-Amino-6(2'-aminophenyl)-1,2,4-triazin-5(4H)-one (2) with an aromatic aldehyde followed by cycloaddition with mercaptoacetic acid afforded the thiazolidinone (4), and treatment with ethyl trifluoroacetate. Structure of the products has been deduced from their correct elemental analysis and spectral measurements. The antifungal activity of the new fluorinated target also has been evaluated.

Synthesis, Characteristic and Antimicrobial Activity of Some New Spiro[indol-thiazolidon-2,4-diones] and Bis(5-fluorospiro[indoline-3,2’-thiazolidine]-2,4’-dione) Probes

“…Recently, the chemistry of 4-thiazolidinone derivatives has been subjected to be much attractive for the chemists, due to their using as core-structure in large hetero-polycyclic-sulfur/nitrogen systems covering a wide range of biological, pharmacological, and medicinal application [1] [2] [3] [4] [5]. Moreover, 4-thiazolidinone derivatives were exhibited anticonvulsant [6], hypnotic [7], antitubercular [8], anthelmintic [9] [10], antimicrobial [11], anticancer [12] [13], antihistaminic [14], antifungal [15], anti-inflammatory [16], andantiviral [17], activities.…”

“…and symm. NO 2 ), 1340 (SO 2 NH 2 ), 1150 (C-S-C), 870, 850, 810 (substituted phenyl) 1. H NMR (400 MHz, DMSO-d 6 ) δ (ppm): 7.88, 7.80, 7.77, 7.72 (each dd, 4H, ArH), 7.41 -7.21, 7.10 -6.99 (each m, 6H, ArH), 4.97 (s, 2H, CH 2 S), 3.85 (2H, SO 2 NH 2 ).…”