Synthesis and Antihypoxic Activity of γ‐L‐Glutamylhistamine and Its Derivatives.

Abstract

Peptides U 0400Synthesis and Antihypoxic Activity of γ-L-Glutamylhistamine and Its Derivatives.-The synthesis of γ-L-glutamylhistamine as well as its derivatives N β -glutarylhistamine and γ-aminobutyrylhistamine is achieved using standard peptide chemistry. Among the three compounds tested, best antihypoxic activity is achieved for γ-L-glutamylhistamine. -(KROMOVA, T. A.; ZHELTUKHINA, G. A.; NEBOL'SIN, V. E.; KOVALEVA, V. L.; KRZHECHKOVSKAYA, V. V.; EVSTIGNEEVA, R. P.; Khim.-Farm. Zh. 39 (2005) 3, 12-15; Lomonosov State Acad. Fine Chem. Technol., Moscow 117571, Russia; Russ., Abstr. Eng.) -Mischke 30-173