Synthesis and Antiinflammatory Activity of Heterocyclic Indole Derivatives.

Rani, Preeti; Srivastava, V. K.; Kumar, Ashok

doi:10.1002/chin.200440117

Cited by 5 publications

(5 citation statements)

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“…All the compounds of this series showed promising anti-inflammatory activity. The most active compound of the series, 3-[1-Acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl] indole 32 was found to be most potent, which had shown higher percent of inhibition of oedema, lower ulcerogenic liability, and acute toxicity than the standard drug phenylbutazone 57 .…”

Section: Fig 41a: Compound 41a 41b: Compound 41bmentioning

confidence: 99%

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2021

IJPSR

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Pharmaceutical chemistry is devoted to the discovery and development of new agents for treating diseases. Inorganic compound continues to be important in therapy, for example, as antacids, mineral supplements, and radiopharmaceuticals, but organic molecules with increasingly specific pharmacological activities are clearly dominant. The five and six-membered heterocyclic nitrogen-containing systems such as pyrazole, imidazole, trizoles, thiozolidine, pyrazolidine, etc., are far by the most important in the ongoing research for more efficacious drugs in the fields such as anti-bacterial, fungicidal, anti-inflammatory, anticonvulsant, diuretics, and anti-histaminic, etc. Pyrazoline is a five-membered heterocyclic compound having two adjacent nitrogen atoms within the ring. It has only one endocyclic double bond and is basic in nature. Pyrazole derivatives have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. The recent success of pyrazole COX-2 inhibitors has further highlighted the importance of these heterocyclic rings in medicinal chemistry. Many scientists have synthesized novel pyrazoline derivatives. They have characterized the synthesized compounds by thin-layer chromatographic technique and analyzed the spectrum by IR, NMR, Mass spectra. Some compounds had been synthesized by the microwave method of synthesis, which is more convenient than the normal method of synthesis. Pyrazoline is a unique template that is associated with several biological activities. This literature high lightened research work of many researchers reported in literature for different pharmacological activities on pyrazole and pyrazoline compounds synthesized.

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Section: Fig 41a: Compound 41a 41b: Compound 41bmentioning

confidence: 99%

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2021

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“…Compounds having pharmacophore such as chloro, fluoro, and bromo groups have exhibited best anti-convulsants 11 , antiinflammatory 12 , anticancer 13 , antitubercular 14 , antibacterial activity 15 , antifungal 16 , and antihistaminic 17 . From the above discussions it may be concluded that the modifications in bis (indolyl) moiety displayed valuable biological activities and these modifications can be utilized to develop potentially active agents.…”

Section: Introductionmentioning

confidence: 99%

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2012

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Gastro-intestinal (GI) toxicity is the common adverse effect which has been associated with most of NSAIDs available in the market. So the search for new therapeutic agents with high margin of safety and freedom from normally associated GI toxic effects has been a priority of pharmacologists and pharmaceutical industries. There are virtually limitless series of structurally novel heterocyclic compounds with a wide range of physical, chemical and biological properties. Literature survey reveals that coupling of two or more biodynamic molecules resulted in the enhanced biological activity. The present work embodied here involves synthesis and evaluation of analgesic and anti-inflammatory activities of some bis (indolyl) methane derivatives.

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“…2-Pyrazoline derivatives have been reported to exhibit various pharmacological activities such as antimicrobial (Karthikeyan et al, 2007;Zitouni et al, 2005aZitouni et al, , 2005b, anti-inflammatory (Bansal et al, 2001;Barsoum et al, 2006;Rani et al, 2004), antihypertensive (Zitouni et al, 2000), antidepressant (Palaska et al, 1996), and monoamine oxidase inhibitory activities (Soni et al, 1987). Similarly, phenolic derivatives such as gallocatechin, epigallocatechin, and caffeic acid, besides their analogs that contain several hydroxy groups on the phenyl moiety, were found to exhibit various useful properties including radical scavenging (Yokozawa et al, 1998), antiviral (Okuda, 2005), antioxidant (Torres de Pinedo et al, 2007), anti-inflammatory (Nazir et al, 2007), antiatherosclerotic properties (Visioli et al, 1995), anti-cancer (Oh et al, 2001), heart protecting (Jang et al, 1997), and strong topoisomerase inhibiting activities (Abdel-Aziz et al, 2004).…”

Section: Introductionmentioning

confidence: 99%