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2-Amino-5-(heteroarylmethylene)-1,3,4-oxadiazoles/thiadiazoles 7-10 were synthesized by cyclisation of 1-(heteroarylacetyl)semicarbazides/thiosemicarbazides 3-6. 5-(2'-Heteroarylmethylene-5'-aminomethylene-1',3,'4'- oxadiazol-2'-yl/thiadiazol-2'-yl)-2-oxo/thiobarbituric acids 11-18 were synthesized by condensation of compounds 7-10 at the 5th position of 2-oxo/thiobarbituric acids. The newly synthesized compounds showed anticonvulsant activity ranging from 50-90% (seizures protection). Compound 18 (5-(2'-phenothiazinylmethylene-5'-aminomethylene-1',3',4'-thiadiazol-2'- yl)-2-thiobarbituric acid) showed maximum activity being more potent than the reference drug phenytoin sodium (CAS 630-93-3).

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515Synthesis and Antiinflammatory Activity of Some New 2,3-Disubstituted-6-monosubstituted-quinazolin-4(3H)-ones. -The synthesis of a series of title compounds as potential anti-inflammatory and less ulcerogenic substances starting from the known quinazolin-4(3H)-one (I) is given. All products are evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. -(RANI, P.; ARCHANA; SRIVASTAVA, V. K.; KUMAR*, A.; Indian J. Chem., Sect. B: Org.

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type (III), (V) and (VII) are prepared and tested for their antiinflammatory activities. Compound (Va) shows the most potent activity. -(RANI, P.; SRIVASTAVA, V. K.; KUMAR*, A.; Eur.