Synthesis and Antiinflammatory Activity of Some New 2,3‐Disubstituted‐6‐monosubstituted‐quinazolin‐4(3H)‐ones.

“…A considerable number of heterocyclic compounds are known to be bioactive. They display antibacterial [14], anti-inflammatory [15] and antimicrobial [16] activities. Compounds having amino acid and sulfonamide moieties are also known to possess a wide range of antibacterial and antifungal activities [17].…”

Section: Introductionmentioning

confidence: 99%

Benzenesulfonylation of Methyl α-D-Glucopyranoside: Synthesis, Characterization and Antibacterial Screening

Kawsar

Nishat

Manchur

et al. 2016

ILCPA

View full text Add to dashboard Cite

A novel series of benzenesulfonyl derivatives of methyl α-D-glucopyranoside (1) were synthesized by reacting benzenesulfonyl chloride in pyridine followed by direct acylation method to yield 6-O-benzenesulfonyl derivative (2). In order to obtain newer products for antibacterial evaluation studies, the 6-O-benzenesulfonyl derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-11) containing a wide variety of functionalities in a single molecular framework. All the synthesized compounds have been confirmed by IR,1H NMR and elemental analysis. These newly synthesized compounds were screened forin vitroantibacterial activity against some human pathogenic bacterial strains. The study revealed that the acylated products exhibit moderate to good antibacterial activities. It was interesting to observe that the selected compounds were more sensitive against Gram-Ve bacteria than that of the Gram-+Ve bacterial strains.

show abstract

“…Quinazolinones are versatile nitrogen containing heterocyclic compounds, possessing a broad spectrum of biological and pharmacological activities such as hypotensive [1], anticancer [2], anti-HIV [3], anti-inflammatory [4], analgesic [5], antiviral [6], antitubercular [7], antimicrobial [8], antibacterial [9,10] etc. Tetrazoles [11,12] are medicinally important heterocycles incorporated in a large number of drugs.…”

Section: Introductionmentioning

confidence: 99%

2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

Arulmurugan¹,

Kavitha²

2010

Molbank

View full text Add to dashboard Cite

This present work aims at synthesizing a novel tetrazole from quinazolinone. 3-(4-Aminophenyl)-2-methyl-3H-quinazolin-4-one is converted into a nitrile by reacting it with acrylonitrile and triton B. The nitrile on treatment with NaN3, NH4Cl and DMF yielded the corresponding tetrazole. The tetrazole obtained was characterized by IR, 1H NMR, EI-MS and elemental analysis. The compound was screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger.The results of the study show that the compound possesses fairly good antimicrobial activity against the test organisms

show abstract

Synthesis and Antiinflammatory Activity of Some New 2,3‐Disubstituted‐6‐monosubstituted‐quinazolin‐4(3H)‐ones.

Cited by 12 publications

References 0 publications

Fluorinated alcohols: A magic medium for the synthesis of heterocyclic compounds

Fluorinated alcohols: A magic medium for the synthesis of heterocyclic compounds

Benzenesulfonylation of Methyl α-D-Glucopyranoside: Synthesis, Characterization and Antibacterial Screening

2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

Contact Info

Product

Resources

About