Synthesis and antiinflammatory, analgesic activity of 3,3′-(1,2-Ethanediyl)-bis[2-aryl-4-thiazolidinone] chiral compounds. Part 10

Vigorita, Maria Gabriella; Ottanà, Rosaria; Monforte, Francesca; Maccari, Rosanna; Trovato, A.; Monforte, M. T.; Taviano, Maria Fernanda

doi:10.1016/s0960-894x(01)00476-0

Cited by 134 publications

(57 citation statements)

References 10 publications

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“…2 Thiazolidin-4-one ring also occurs in nature; thus actithiazic acid [(-) 2-(5-carboxypentyl) thiazolidin-4-one)] isolated from Streptomyces strains exhibits highly specific in vitro activity against…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial activity of some novel 2-Aroylimino-3-aryl-thiazolidin-4-ones

Saeed¹,

Abbas²,

Flörke³

2007

J. Braz. Chem. Soc.

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Este trabalho relata uma síntese eficiente e regio-seletiva de algumas 2-aroylimino-3-arylthiazolidin-4-ones (2a-j) envolvendo a ciclização de 1-aroyl-3-aryl tio-uréias em meio básico com cloreto de cloroacetila em dioxana. As estruturas foram confirmadas por dados espectroscópicos, análises elementares e, em um caso (2j), por dados de difração de raios X tipo cristal único. Os compostos foram testados in vitro quanto à sua atividade antimicrobiana em relação a bactérias Gram positivas e Gram negativas. Os resultados revelaram uma atividade promissora desses compostos em relação aos microorganismos testados, comparando-se e, em alguns casos, até superando a atividade das drogas existentes.An efficient, regioselective synthesis of some 2-aroylimino-3-aryl-thiazolidin-4-ones (2a-j) involving base-catalyzed cyclization of 1-aroyl-3-aryl thioureas with chloroacetyl chloride in dioxane is reported. The structures were confirmed by spectroscopic data, elemental analyses and in one case (2j) by single crystal X-ray diffraction data. Compounds (2a-j) were assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria and were found to exhibit promising activity towards the tested microorganisms, comparable to and in some cases better than those of the standard drugs.

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Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial activity of some novel 2-Aroylimino-3-aryl-thiazolidin-4-ones

Saeed¹,

Abbas²,

Flörke³

2007

J. Braz. Chem. Soc.

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“…Based on the "p" value, Compound-2 and 3 showed higher significance from 1 hr to 5 hrs when compared with control [26]. It was found that the electron withdrawing groups and alkene containing synthesized compounds enhanced the anti-inflammatory activity.…”

Section: Resultsmentioning

confidence: 93%

“…The anti-inflammatory studies revealed that all the synthesized novel 1,2-diazole derivatives showed significant anti-inflammatory activity, when compared with that of standard drug diclofenac sodium. NP-2 and NP-3 showed greater pharmacological activity due to the presence of -Cl and -NO 2 and electron withdrawing groups [26], whereas, NP-5, NP-4 and NP-1 showed mild to moderate activity [27] [28].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Biological Activity Study of Novel N1-(4-Hydroxy Benzoyl)-3-Methyl-5-Phenyl-4(N-4-Chlorophenylazo)-1,2-Diazole and Its Derivatives

Bhatt¹,

Singh²,

Kumar³

et al. 2017

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A series of sulpha/substituted derivatives of phenyl azo-1,2-diazole have been synthesized and tested as an anti-inflammatory and anti-bacterial activity in mature albino rats hind paw by taking Diclofenac sodium as standard. N 1 -(4-hydroxy benzoyl)-3-methyl-5-phenyl-4(N-4-chlorophenylazo)-1,2-diazole is synthesized by a two-step process. In the first step, synthesis of N 1 -4-chlorophenyl hydrazono-1-methyl-3-phenyl propane-1,3-dione by the reciprocal action of 1-methyl-5-phenylpropane-1,3-dione and diazonium salt solution of phenyl-chloride interacts with 4-hydroxybenzoic acid hydrazide to form the final compound. These diazoles, the heterocyclic compounds which contained electron withdrawing groups, were screened for analgesic activity by acetic acid induced writing method, and for anti-inflammatory activity carried on carrageenan-induced paw edema. The synthesized substituted Chlorophenylazo-1,2-diazole nucleus exhibited significant anti-bacterial, anti-cancer, anti-inflammatory activity, muscle relaxing and moderate activity in anti-proliferative studies.

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“…Among the small ring heterocyclic's containing nitrogen and sulphur 4-thiazolidinones have been under investigation for a long time because of their excellent biological properties such as antibacterial [22][23] , antifungal [22][23] , antituberculostatic [24][25] , anti-HIV 26 , anticancer 27 , anticonvulsant 28 , anti-inflammatory 29 , analgesic 29 etc. The biological significance of this class of compounds and multidrug resistance of several Gram-positive microbes impelled us to continue working on the synthesis and antimicrobial screening against some typical Gram-positive bacteria and fungi of new thiazolidinone derivatives.…”

mentioning

confidence: 99%

Synthesis and Antimicrobial Assay of Some Ketoanils and their Thiazolidinones

Raghav¹,

Upadhyay²,

Upadhyay³

2013

Orientjchem.

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Synthesis and antiinflammatory, analgesic activity of 3,3′-(1,2-Ethanediyl)-bis[2-aryl-4-thiazolidinone] chiral compounds. Part 10

Cited by 134 publications

References 10 publications

Synthesis and antibacterial activity of some novel 2-Aroylimino-3-aryl-thiazolidin-4-ones

Synthesis and antibacterial activity of some novel 2-Aroylimino-3-aryl-thiazolidin-4-ones

Synthesis and Biological Activity Study of Novel N1-(4-Hydroxy Benzoyl)-3-Methyl-5-Phenyl-4(N-4-Chlorophenylazo)-1,2-Diazole and Its Derivatives

Synthesis and Antimicrobial Assay of Some Ketoanils and their Thiazolidinones

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