Synthesis and antimalarial activity of novel chiral and achiral benzenesulfonamides bearing 1, 3, 4-oxadiazole moieties

Design, synthesis, and pharmacological studies of some new Mannich bases and S-alkylated analogs of pyrazole integrated 1,3,4-oxadiazole

“…The potent pharmacological activity of 1,3,4-oxadiazoles can be attributed to the presence of -N=C=O linkage, which reacts with nucleophilic centers of microbial cells [18]. Several oxadiazoline derivatives have been reported [1,3,4] to possess significant biological activities such as antimicrobial [19], antimalarial [20], analgesic [21], antiinflammatory [22], antiviral [23], antitumor [24], anticonvulsant [25], and antidiabetic properties [26], among others. In particular, the most prominent examples featuring a 1,3,4-oxadiazole nucleus include the antiretroviral raltegravir, the antihypertensive nesapidil, the antibiotic furamizole, etc.…”

Immunomodulatory properties of S- and N-alkylated 5-(1H-indol-2-yl)-1,3,4-oxadiazole-2(3H)-thione

“…They are also used as physiological modulators, such as inhibitors of human liver glycogen phosphorylase 16 , aromatase 17 and human cytosolic phospholipase A 2 α 18 . The1,3,4-oxadiazoles have showed anti-inflammatory, analgesic 19 , antimicrobial 20 , antimalarial 21 , antiproliferative 22 , and antituberculosis 23 activities. Literature survey revealed that, coupling of two biodynamic heterocyclic systems emerges conjugates of talented biological activities, for instance, indolyloxadiazoles were reported as efficient anti-inflammatory 24,25 and antibacterial 26 candidates.…”

Synthesis of 1,3,4-oxadiazole derivatives from α-amino acid and acyl hydrazides under thermal heating or microwave irradiation conditions

“…These derivative compounds have been found to exhibit diverse biological activities such as analgesic, 1,2 anti-inflammatory, 1,2 antimicrobial, [2][3][4] anti-HIV, 5 antimalarial, 6,7 antifungicidal, 8,9 and other biological properties. [10][11][12][13][14] Some 1,3,4-oxadiazole derivatives have also been applied in the fields of photosensitizers, 15 liquid crystals 16,17 and organic light-emitting diodes (OLED).…”