Synthesis and antimicrobial activity of N-[(α-methyl)benzylidene]-(3-substituted-1,2,4-triazol-5-yl-thio)acetohydrazides

Ersan, Seyhan; Nacak, Sultan; Berkem, Rukiye

doi:10.1016/s0014-827x(98)00095-0

Cited by 35 publications

(11 citation statements)

References 7 publications

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“…Ampicillin is able to penetrate gram-positive and some gram-negative bacteria 17 . Ampicillin acts as a competitive inhibitor of enzyme transpeptidase.…”

Section: Biological Activitymentioning

confidence: 99%

Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives

Singh¹,

Singh²

2009

Journal of Chemistry

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Syntheses of a series of 3-alkyl-4-amino-5-cyanomethyl-4H-1, 2, 4-triazoles with active methylene groups are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. All the compounds carrying 1, 2, 4-triazole moiety showed significant biological activity.

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“…Ampicillin is able to penetrate gram-positive and some gram-negative bacteria 17 . Ampicillin acts as a competitive inhibitor of enzyme transpeptidase.…”

Section: Biological Activitymentioning

confidence: 99%

Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives

Singh¹,

Singh²

2009

Journal of Chemistry

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“…It reveals that 1,2,4 and 1,2,3-triazoles possess broad spectrum of activities such as antimicrobial [1][2][3][4] , anti-inflammatory 5 , analgesic 6 , antitumorial 7 , antihypertensives 8 , anticonvulsant and antiviral 9 . Some of the antimicrobial triazole derivatives used as common antibiotics such as Amphotericin B possess toxic effect on humans along with their antimicrobial effects 10 .…”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES

Mishra

Kumar

et al. 2010

J. Chil. Chem. Soc.

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Some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazol (3a-3f) and N- [5-(4-substituted)-1H-1,2,3-triazol-1-yl]isonicotinamide derivatives (5a-5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 and 2. The antibacterial and antifungal activities of newly synthesized compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus niger and Candida albicans. Ciprofloxacin and Fluconazole at 50 μg/mL were used as standard drugs for antibacterial and antifungal activities, respectively. All the synthesized compounds showed significant activity against various microorganisms.

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“…Ampicillin is designated chemically as (2S, 5R, 6R)-6-([(2R)-2amino-2-phenylacetyl] amino)-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2carboxylicacid. Ampicillin is able to penetrate gram-positive and some gram-negative bacteria 14 . Ampicillin acts as a competitive inhibitor of enzyme transpeptidase.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Novel Syntheses of Some 1, 2, 4‐Triazoles as Potent Bacteriocidal Agents

Singh

2009

Journal of Chemistry

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A facile syntheses of 4-aryl-5-(isomeric pyridoyl)-3H-1, 2, 4-triazoles as potent bacteriocidal agents are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity againstS. aureus, E. coli, B. subtilisandP.aeruginosa.All compounds carrying 1, 2, 4- triazole moiety showed significant biological activity

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Synthesis and antimicrobial activity of N-[(α-methyl)benzylidene]-(3-substituted-1,2,4-triazol-5-yl-thio)acetohydrazides

Cited by 35 publications

References 7 publications

Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives

Syntheses, Characterization and Biological Activity of Some 1, 2, 4‐Triazole Derivatives

SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES

Novel Syntheses of Some 1, 2, 4‐Triazoles as Potent Bacteriocidal Agents

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