Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines

Triazine as a promising scaffold for its versatile biological behavior

“…Introduction of fluorine substituents to biologically active piperazine ring can affect their biological properties associated with lipophilicity, absorption, and transportation[71]. Substitution of triazine ring[72] with 3-or 4-fluorophenyl along with rigid diamine as one of substitutent was preferred, since activity was increased by introducing rigidity at this position such as isopentyl (48a), cyclopentylmethyl (48b), cyclohexyl methyl (48c), benzyl amine (48d), piperidine (48e) and tetramethylpiperidine (48f). Among other rigid amines, compounds 48e or 48f showed most effective substituents against antimicrobial activity(Fig.…”

Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds

“…Additionally, it has also been reported that certain s -triazine derivatives possess potent antimicrobial activity [10–12] and have been explored by researchers successfully to yield potent antimicrobial agents. For example, compounds having thiazole nucleus attached with this structural motif displayed promising antifungal activity [13].…”

Study of new β-lactams-substituted s-triazine derivatives as potential bioactive agents

“…Besides its wellknown antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers (Chimento et al, 2013;Jaishree et al, 2012;Bhati and Kumar, 2008;Halve et al, 2007). Moreover, s-triazine derivatives have gained great therapeutic importance in the field of medicinal chemistry since they display a fascinating array of pharmacological properties, such as antimicrobial (Patel et al, 2013b), antifungal (Saleh et al, 2010), antibacterial (Patel et al, 2012), anticancer (Kumar et al, 2013), anti-HIV (Chen et al, 2012), anti-inflammatory (Shanmugakala et al, 2014), antimalarial (Ojha et al, 2011), etc. In our continuous effort toward synthesis of bioactive s-triazine derivatives (Patel et al, 2014b), we report the synthesis of various benzonitrile/nicotinonitrile and azetidin-2-one incorporated s-triazine compounds by applying an efficient Pd-catalyzed C-C Suzuki coupling using catalyst system Pd(OAC) 2 , Xphos (2-dicyclohexylphosphino-2 0 ,4 0 ,6 0 -triisopropylbiphenyl), and K 3 PO 4 as a base in toluene solvent. The antimicrobial activity of synthesized compounds has been carried out against two Gram-positive bacteria, three Gram-negative bacteria, and two fungal species.…”