Synthesis and Antimicrobial Activity of Some New Substituted Aryloxy‐4‐Thiazolidinones

Kumar, Prasoon; Yadav, Monika; Kumar, M. Murali Krishna; Rao, T. Siva

doi:10.1155/2006/513489

Cited by 8 publications

(2 citation statements)

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“…Organic compounds containing five membered heterocyclic ring like; 1, 2, 3-triazole, pyrazole and thiazolidinone have occupied unique place in the field of medicinal chemistry due to their diverse biological activities such as: antifungal [1], antimicrobial [2,3,4], antiflammatory [5,6], cytotoxicity [7], antioxidant [8], antihistaminic [9], antituberculor [10] and anticonvulsant [11]. Recently it was found that 1,2,3-triazoles could be used as a peptide surrogates in the rapid synthesis of HIV-1 protease inhibitors [12] and as cis peptide bond surrogate in protein prosthesis [13].It was found that pyrazole and 4-thiazolidinone derivatives have additional industrial applications [14], [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Some New 1,2,3-Triazole, Pyrazolin-5-one and thiazolidinone Derivatives

Hassan

2013

JNUS

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Five membered heterocyclics derivatives were synthesized in this work by three routes. The first route includes the synthesis of N-benzoic acid 1,2,3,-triazole derivatives (3),(4) by diazotation of methyl-2-amino benzoate and treating the resulted salt (1) with sodium azide and ethyl acetoacetate or acetyl acetone, respectively. In the second route, derivatives of pyrazole (8) pyrazolin-5-one (9), (10) were prepared by the reaction of the salt (1) with some active methylene compounds to give the corresponding hydrazones derivatives (5-7) which then they were treated with hydrazine hydrate. The third route afforded the synthesis of three derivatives (12), (15a), (15b) of thiazolidinone by two different methods. AII compounds were confirmed by their melting points, FTIR, U.V-vis spectra and 1 H-NMR spectra for some of them.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Some New 1,2,3-Triazole, Pyrazolin-5-one and thiazolidinone Derivatives

Hassan

2013

JNUS

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“…4-Thiazolidinone derivatives are known to exhibit diverse bioactivities such as antibacterial (Mishra et al, 2007;Aquino et al, 2008;Bondock et al, 2007;Shah et al, 2007;Kumar et al, 2006;Rida et al, 2005), antifungal (Özkirimli et al, 2008;Kaplancikli et al, 2008;Siddiqui et al, 2003), antituberculosis (Küçükgüzel et al, 2002;Küçükgüzel et al, 2006;Karali et al, 2007), anti-HIV (Rawal et al, 2008;Balzarini et al, 2007;Rao et al, 2003), anticancer (Ali et al, 2007), anticonvulsant (Archana et al, 2002;Amin et al, 2008;Gürsoy et al, 2005), anti-inflammatory (Kumar et al, 2009;Bhati et al, 2008;Goel et al, 1999) and antihistaminic (Diurno et al, 1999) activities. On the other hand, α,α-diphenyl-α-hydroxy)acetyl moiety are also associated with various biological properties including antimicrobial activity Ilhan et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial evaluation of new 3-alkyl/aryl-2-[((α,α-diphenyl-α-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones

et al. 2010

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New 4-thiazolidinone derivatives of benzilic acid (alpha,alpha-diphenyl-alpha-hydroxyacetic acid) have been synthesized and evaluated for antibacterial and antifungal activities. The reaction of 1- (alpha,alpha-diphenyl-alpha-hydroxy)acetyl-4-alkyl/arylthiosemicarbazides with ethyl 2-bromopropionate gave 3-alkyl/aryl-2-[((alpha,alpha-diphenyl-alpha-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinone derivatives. Their antibacterial and antifungal activities were evaluated against S. aureus ATCC 29213, P. aeruginosa ATCC 27853, E. coli ATCC 25922, C. albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, T. mentagrophytes var. erinacei NCPF 375, M. gypseum NCPF 580 and T. tonsurans NCPF 245. 3e, 3f, 3g and 3h showed the highest antibacterial activity. Particularly 3a and 3e showed the highest antifungal activities against C. parapsilosis ATCC 22019, T. tonsurans NCPF 245 and M. gypseum NCPF 580.

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Quantitative Nuclear Magnetic Resonance Spectroscopic Analysis of Two Commonly Used Gastrointestinal Tract Drugs

El‐Bagary

Fouad

Ezzeldin

2020

Journal of AOAC INTERNATIONAL

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Background Two fast and precise quantitative nuclear magnetic resonance spectroscopic methods (qNMR) were established and evaluated for the determination of ondansetron (OND) and omeprazole (OMP) in bulk drugs and their pharmaceutical dosage forms. NMR spectra were established using dimethylsulfoxide (DMSO-d6) as a solvent and phloroglucinol as the internal standard. Proton NMR signals at 3.743, 3.811, and 5.670 ppm were used for quantitative monitoring purposes corresponding to OND, OMP, and phloroglucinol, respectively. In this study, the methods linearity, accuracy, limit of quantification, limit of detection, stability, and precision were validated as per International Conference on Harmonization (ICH) guidelines. Linearity ranges were 0.3–10 mg for OND and 1–10 mg for OMP. The student t-test and F-test were used for statistical evaluation. Herein, the proposed methods are useful and can be a successful practical appliance for OND and OMP determination in drug substances and their dosage forms.

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Synthesis and Antimicrobial Activity of Some New Substituted Aryloxy‐4‐Thiazolidinones

Abstract: Nine new substituted aryloxy-4-thiazolidones have been prepared from corresponding schiff bases and thioglycolic acid in benzene using Stark and Dien apparatus. The synthesized compounds were identified by spectral studies and screened for antimicrobial activity.

Cited by 8 publications

References 1 publication

Synthesis and Characterization of Some New 1,2,3-Triazole, Pyrazolin-5-one and thiazolidinone Derivatives

Synthesis and Characterization of Some New 1,2,3-Triazole, Pyrazolin-5-one and thiazolidinone Derivatives

Synthesis and antimicrobial evaluation of new 3-alkyl/aryl-2-[((α,α-diphenyl-α-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones

Quantitative Nuclear Magnetic Resonance Spectroscopic Analysis of Two Commonly Used Gastrointestinal Tract Drugs

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