Synthesis and antimicrobial activity of novel 3 substituted 1,5‐dihydro‐2,4,3‐benzodioxaphosphepine 3‐oxides

Abstract

Novel 3 substituted 1,5-dihydro-2,4,3-benzodioxaphosphepine 3-oxides (5a-h)

Phosphine Oxides from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery

“…In contrast, the synthesis of cyclic alkyl arylphosphonates III by the reaction of a nucleophilic arylmetal species with a corresponding cyclic chlorophosphate is rather challenging (Scheme , D) . However, cyclic alkyl arylphosphonates III , -amidates IV , and -amides V are readily accessible by the reaction of arylphosphonyl dichlorides with diols, amino alcohols, and diamines (Scheme , E).…”

Synthetic, spectral as well as in vitro antimicrobial studies on some bismuth(III) bis(N,N‐dialkyldithiocarbamato) alkylenedithiophosphates

“…With regards to structural studies, these ligands often display bidentate coordination patterns, which may be isobidentate (symmetrical) or anisobidentate (unsymmetrical) both in chelating and bridging situations. In addition to peculiar structural properties, these ligands continue to attract attention owing to their diverse range of applications, such as dithiocarbamates, which have useful applications as a sulfur source for vapor deposition and nanoparticle growth of metal sulfide materials,12, 13 as single‐source precursors for metallo‐organic chemical vapour deposition (MOCVD) of nanosized particles of tin14 and bismuth15 sulfide thin films along with dithiocarbamates, alkylenedithiophosphates are well known for their antifungal and antibacterial16, 17 properties. On the other hand despite being a heavy metal, bismuth finds many applications in medicines and in the treatment of gastrointestinal disorders,18, 19 and has anticancer and antitumor20 properties.…”