Synthesis and Antimicrobial activity of some new Schiff bases

Karamunge, Khushal G.; Vibhute, Yaswant B.

doi:10.1088/1742-6596/423/1/012006

Cited by 7 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the context of our studies in ferrocenyl medicinal chemistry, , we became interested in how the introduction of an additional redox-active group might affect the biological effects of flavonoids. Several coordination complexes with chalcones and other flavonoids are known; indeed, the ability of flavonoids to coordinate metals is considered to be part of their antioxidant arsenal . Examples of organometallic flavonoids, on the other hand, are rarer.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structural Characterization of Ferrocenyl-Substituted Aurones, Flavones, and Flavonols

et al. 2011

View full text Add to dashboard Cite

In the context of our studies on the modification of bioactive molecules with ferrocene, we here report the first examples of ferrocenyl flavonoids, where ferrocene replaces the B ring of the flavonoid skeleton. Ferrocenyl aurones possessing an electron-withdrawing or an electron-donating group in the 5′-position were obtained from 5′-R-2′-hydroxy-3-ferrocenyl chalcones via 1,5 oxidative exocyclization using Hg(OAc)2 or AgOTf. Treatment of the ferrocenyl aurones with LDA resulted in a ring opening to form ferrocenyl ynones, which could then be selectively recyclized to the flavone isomer by treatment with NaOEt. Ferrocenyl flavones were also obtained by isomerization of the aurones with KCN and were hydroxylated in the 3-position to form ferrocenyl flavonols with oxone in a biphasic reaction. In many cases the reactivity of the ferrocenyl compounds was significantly different from that of their organic analogues. This reactivity and regioselectivity can be rationalized by ferrocene’s particular ability to destabilize α-anions in reaction intermediates. Representative examples of ferrocenyl aurones, ynones, and flavones were characterized by 2D NMR and X-ray crystallography, and the molecules all show a planar arrangement of the organic skeleton with the cyclopentadienyl ring of the ferrocene group. Putative MLCT bands in the visible region are responsible for the variety of highly saturated colors observed.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Structural Characterization of Ferrocenyl-Substituted Aurones, Flavones, and Flavonols

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Schiff bases are interesting class of ligands that have shown interdisciplinary domains as they possess a diversity of donor atoms that exhibit remarkable activity. Such activities include corrosion inhibition, catalysts, biological activity, chemo-sensor, material science [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Electrochemical Studies of Schiff Bases Containing 4-Aminobenzoic Acid Moeity

Ejiah,

Rofiu,

Akitoye

et al. 2024

JCSN

View full text Add to dashboard Cite

The use of Schiff bases in material science, therapeutics and sensor has been achieved due to its electrochemical potentials. In this study, Schiff bases of 4-((2-hydroxybenzylidene)amino)benzoic acid (G1) and 4-((5-bromo-2-hydroxybenzylidene)amino)benzoic acid (G2) were synthesized from 4-aminobenzoic acid. The compounds were characterized using FTIR, ESI-MS and 1H NMR which confirm the synthesized compounds. The electrochemical behaviour of both ligands was studied in triethylammonium phosphate acetonitrile solution. The cyclic voltammetry of G1 and G2 Schiff bases resembled voltammograms with one or two quasi-reversible redox processes, indicating redox potentials of the ligands. The electrochemical screening showed that the ligands would exhibit significant binding interactions with molecules such as metal ions and biological models.

show abstract

Synthesis, characterization and antibacterial activity studies of new 2-pyrral-L-amino acid Schiff base palladium (II) complexes

et al. 2020

View full text Add to dashboard Cite

show abstract

Synthesis and Antimicrobial activity of some new Schiff bases

Cited by 7 publications

References 7 publications

Synthesis and Structural Characterization of Ferrocenyl-Substituted Aurones, Flavones, and Flavonols

Synthesis and Structural Characterization of Ferrocenyl-Substituted Aurones, Flavones, and Flavonols

Synthesis, Characterization and Electrochemical Studies of Schiff Bases Containing 4-Aminobenzoic Acid Moeity

Synthesis, characterization and antibacterial activity studies of new 2-pyrral-L-amino acid Schiff base palladium (II) complexes

Contact Info

Product

Resources

About