Synthesis and antimicrobial activity of pyrazolyl benzoxazoles, benzothiazoles and benzimidazoles

Reddy, L. Mallikarjuna; Prakash, T. Bhanu; Padmaja, A.; Padmavathi, V.

doi:10.1007/s00044-014-1180-0

Cited by 13 publications

(3 citation statements)

References 18 publications

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“…Reddy et al, reported the synthesis of a new class of pyrazolyl–benzimidazoles 23a – 23c possessing an amide group by reaction between pyrazolones 21a – 21c with 1 H -benzo[d]imidazol-2-amine 9 , and the oxidation of the intermediate compounds 22a – 22c with chloranil ( Scheme 7 ) [ 61 ]. It was found that the presence of electron-withdrawing substituent “Cl” on the aromatic ring increases the antimicrobial activity, compound 23c being a potent antifungal agent against A. niger considering ketoconazole as standard.…”

Section: Synthesis Antimicrobial Activities Of Benzimidazole–pyrazole Compounds Benzimidazole–pyrazole Compounds As Potent Dna Gyrase Andmentioning

confidence: 99%

Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

Marinescu

2021

Antibiotics

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The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer’s, antiulcer, antidiabetic. Moreover, recent literature mentions the syntheses and antimicrobial properties of some benzimidazole–pyrazole hybrids, as well as other biological properties thereof. In this review, we aim to review the methods of synthesis of these hybrids, the antimicrobial activities of the compounds, their correlation with various groups present on the molecule, as well as their pharmaceutical properties.

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Section: Synthesis Antimicrobial Activities Of Benzimidazole–pyrazole Compounds Benzimidazole–pyrazole Compounds As Potent Dna Gyrase Andmentioning

confidence: 99%

Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

Marinescu

2021

Antibiotics

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“…Several methods for synthesis of 2-aminobenzoxazoles have been reported (Scheme ). ,− However, most of these methods suffer from specific drawbacks. The most published protocol comprises the cyclization of 2-aminophenols using BrCN as a cyanating agent, ,− , but this BrCN reagent is highly toxic.…”

Section: Introductionmentioning

confidence: 99%

“… ,− However, most of these methods suffer from specific drawbacks. The most published protocol comprises the cyclization of 2-aminophenols using BrCN as a cyanating agent, ,− , but this BrCN reagent is highly toxic. The next reported approach is the direct 2-C amination of benzoxazoles, − but its drawbacks include the use of transition metal catalysts, high temperatures, nitrogen atmosphere, or co-oxidants.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Various 2-Aminobenzoxazoles: The Study of Cyclization and Smiles Rearrangement

2019

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This study reports two synthetic approaches leading to 2-aminobenzoxazoles and their N-substituted analogues. Our first synthetic strategy involves a reaction between various o-aminophenols and N-cyano-N-phenyl-p-toluenesulfonamide as a nonhazardous electrophilic cyanating agent in the presence of Lewis acid. The second synthetic approach uses the Smiles rearrangement upon activation of benzoxazole-2-thiol with chloroacetyl chloride. Both developed synthetic protocols are widely applicable, afford the desired aminobenzoxazoles in good to excellent yields, and use nontoxic and inexpensive starting material.

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Synthesis and Antibacterial Activity of Sulfur‐linked Bis and Tris Heterocycles

Reddy

Goodla

Teja

et al. 2017

Journal of Heterocyclic Chem

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The bis and tris heterocycles‐benzoxazolyl/benzothiazolyl/benzimidazolyl quinazolines linked by sulfur and/or nitrogen were prepared from 2,4‐dichloroquinazoline and benzazolyl‐2‐thiol/benzazolyl‐2‐amine and studied their antibacterial activity. The nitro‐substituted sulfur‐linked bisbenzothiazolylquinazoline (12f), bisbenzimidazolylquinazoline (13f), and nitro‐substituted sulfur and nitrogen‐linked bisbenzothiazolylquinazoline (15f) were found to be potential antibacterial agents against Staphylococcus aureus.

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Synthesis and antimicrobial activity of pyrazolyl benzoxazoles, benzothiazoles and benzimidazoles

Cited by 13 publications

References 18 publications

Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

Synthesis of Various 2-Aminobenzoxazoles: The Study of Cyclization and Smiles Rearrangement

Synthesis and Antibacterial Activity of Sulfur‐linked Bis and Tris Heterocycles

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