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A new class of mono and bis heterocycles, sulfonylmethaneamido linked oxazoles, thiazoles, imidazoles, pyrrolyl oxazoles, pyrrolyl thiazoles and pyrrolyl imidazoles were prepared adopting simple and versatile synthetic methodologies. The compound chloro substituted imidazolyl styrylsulfonylacetamide is the most potent antimicrobial agent particularly against Pseudomonas aeruginosa and Penicillium chrysogenum.

Synthesis of Some New 2-(Benzylsulfonylethylsulfonylmethyl)oxazolines and Thiazolines. -Alternative routes for the synthesis of the title compounds (IV) and (VI) are described. The microwave method provides an excellent approach for the safe, rapid, inexpensive and simple synthesis of oxazolines (IV) and thiazolines (VI). -(PADMAVATHI*, V.; PREMAKUMARI, C.; VENKATESH, B. C.; PRAKASH, T. B.; PADMAJA, A.; Indian J.